Kinin B1 receptor controls maternal adiponectin levels and influences offspring weight gain

Author(s)

Alves-Silva, Thais ; Hungaro, Talita G. R. ; Freitas-Lima, Leandro C. ; Arthur, Gabriel de Melo ; Arruda, Adriano C. ; Santos, Raisa B. ; Oyama, Lila M. ; Mori, Marcelo A. S. ; Bader, Michael ; Araujo, Ronaldo C.

• Document type: Journal article
• Source: ISCIENCE; v. 26, n. 12, p. 19-pg., 2023-11-18.

Abstract

Given the importance of the kinin B1 receptor in insulin and leptin hormonal regulation, which in turn is crucial in maternal adaptations to ensure nutrient supply to the fetus, we investigated the role of this receptor in maternal metabolism and fetoplacental development. Wild-type and kinin B1 receptor-deficient (B1KO) female mice were mated with male mice of the opposite genotype. Consequently, the entire litter was heterozygous for kinin B1 receptor, ensuring that there would be no influence of offspring genotype on the maternal phenotype. Maternal kinin B1 receptor blockade reduces adiponectin secretion by adipose tissue ex vivo , consistent with lower adiponectin levels in pregnant B1KO mice. Furthermore, fasting insulinemia also increased, which was associated with placental insulin resistance, reduced placental glycogen accumulation, and heavier offspring. Therefore, we propose the combination of chronic hyperinsulinemia and reduced adiponectin secretion in B1KO female mice create a maternal obesogenic environment that results in heavier pups. (AU)

• FAPESP's process: 15/20082-7 - Kallikrein kinin system in physical exercise and metabolism
• Grantee: Ronaldo de Carvalho Araújo
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 21/08354-2 - The interplay between the immune system and metabolism as a key determinant of the aging process
• Grantee: Marcelo Alves da Silva Mori
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 17/21368-7 - Role of kinin B1 receptor in maternal metabolism induced by physical training during the pregnancy
• Grantee: Thaís Alves da Silva
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)