| Full text | |
| Author(s): |
Cipelli, Marcella
;
da Silva, Eloisa Martins
;
Camara, Niels Olsen Saraiva
Total Authors: 3
|
| Document type: | Journal article |
| Source: | CURRENT CLINICAL MICROBIOLOGY REPORTS; v. 10, n. 4, p. 11-pg., 2023-10-07. |
| Abstract | |
Purpose of ReviewAlthough extensive research has been conducted on microbial resilience, numerous unanswered questions persist. In this study, we highlight impactful research that elucidates the diverse mechanisms underlying the resilience of the gut microbiota against pathogen colonization and its implications on gut health and disease.Recent FindingsThe increasing importance of gut microbiota resistance in the context of pathogenic infections has been extensively reported. The establishment of a homeostatic microbiome-host interaction, facilitated by intricate mechanisms originating from both the microbiota and the host, plays a crucial role in fostering resilience. However, pathogens have evolved several evasion strategies that can disrupt healthy microbiota composition, trigger environmental alterations, and induce inflammation, thereby potentially exacerbating inflammatory diseases in the gut.SummaryIn this review, we aim to highlight the significance of different resilience mechanisms during intestinal infections and their potential for modulation to develop new interventions that can effectively ameliorate Inflammatory Bowel Disease (IBD). (AU) | |
| FAPESP's process: | 20/14388-4 - Incretin signal in tumor progression in the experimental model of Colorectal Cancer associated with Colitis |
| Grantee: | Eloisa Martins da Silva |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |
| FAPESP's process: | 17/05264-7 - Cell metabolism, microbiota and immune system: new paradigms in renal diseases physiopathology |
| Grantee: | Niels Olsen Saraiva Câmara |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 18/24350-4 - Metabolic characterization of Foxp3+ RORgt+ T cell population in the experimental model of Colitis-associated colorectal Cancer |
| Grantee: | Marcella Cipelli |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |