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Analysis of fibrinogenolytic activity of South American Bothrops and Crotalus venoms reveals widespread variation on human fibrinogen cleavage

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Author(s):
Soares, Maria Victoria Motta ; Galizio, Nathalia da Costa ; da Rocha, Marisa Maria Teixeira ; Grego, Kathleen Fernandes ; Tanaka-Azevedo, Anita Mitico ; de Morais-Zani, Karen
Total Authors: 6
Document type: Journal article
Source: Toxicon; v. 255, p. 5-pg., 2025-01-13.
Abstract

Fibrinogen is a common target of SVMP and SVSP. These toxins can destructively cleave fibrinogen, leading to the depletion of its levels. Herein we comparatively describe the fibrinogenolytic activity of the venom of Bothrops and Crotalus snakes, viperids of high epidemiological importance in Brazil. Results emphasize species- specific differences in the degradation rate and the specificity of the preferentially degraded fibrinogen chains, reflecting the complexity of the coagulotoxic effects induced by envenomation. (AU)

FAPESP's process: 24/01795-1 - Investigating degradation of basement membranes by Bothrops snake venoms to determine strategies for medical intervention
Grantee:Nathália da Costa Galizio
Support Opportunities: Scholarships abroad - Research Internship - Doctorate
FAPESP's process: 23/00670-8 - Unravelling the mechanism of snake venom induced haemorrhage by focusing on basement membrane disruption
Grantee:Karen de Morais Zani
Support Opportunities: Regular Research Grants
FAPESP's process: 21/07627-5 - Investigation of coagulotoxicity of snake venom species from Viperidae family of medical importance in Brazil.
Grantee:Nathália da Costa Galizio
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 20/07268-2 - Characterization of the coagulotoxic profile of venoms of Viperidae snakes with medical importance in Brazil
Grantee:Karen de Morais Zani
Support Opportunities: Regular Research Grants