| Full text | |
| Author(s): |
Pereira, Lucas Matheus Soares
;
Taveira, Iasmin Cartaxo
;
Maues, David Batista
;
de Paula, Renato Graciano
;
Silva, Roberto N.
Total Authors: 5
|
| Document type: | Journal article |
| Source: | Applied Microbiology and Biotechnology; v. 109, n. 1, p. 21-pg., 2025-01-01. |
| Abstract | |
Second-generation (2G) bioethanol production, derived from lignocellulosic biomass, has emerged as a sustainable alternative to fossil fuels by addressing growing energy demands and environmental concerns. Fungal sugar transporters (STs) play a critical role in this process, enabling the uptake of monosaccharides such as glucose and xylose, which are released during the enzymatic hydrolysis of biomass. This mini-review explores recent advances in the structural and functional characterization of STs in filamentous fungi and yeasts, highlighting their roles in processes such as cellulase induction, carbon catabolite repression, and sugar signaling pathways. The review also emphasizes the potential of genetic engineering to enhance the specificity and efficiency of these transporters, overcoming challenges such as substrate competition and limited pentose metabolism in industrial strains. By integrating the latest research findings, this work underscores the pivotal role of fungal STs in optimizing lignocellulosic bioethanol production and advancing the bioeconomy. Future prospects for engineering transport systems and their implications for industrial biotechnology are also discussed. (AU) | |
| FAPESP's process: | 22/01751-9 - Engineering of Trichoderma reesei xylose transporters to improve the Saccharomyces cerevisiae sugar transport system |
| Grantee: | Iasmin Cartaxo Taveira |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 19/11655-4 - Functional studies of gene regulatory networks in Trichoderma reesei during the cellulases formation |
| Grantee: | Roberto do Nascimento Silva |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 22/14399-1 - Functional characterization and overexpression of potential cellobiose and xylose transporters in Trichoderma reesei during cellulase production |
| Grantee: | Lucas Matheus Soares Pereira |
| Support Opportunities: | Scholarships in Brazil - Doctorate |