| Full text | |
| Author(s): Show less - |
Oliveira, Maria D. A.
;
Andrade, Teresinha de Jesus A. dos S.
;
Joaquim Jr, S. C.
;
Lima, Nerilson Marques
;
Machado, Hugo G.
;
Tabudravu, Jioji N.
;
Pinto, Francisco das Chagas L.
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Fukui-Silva, Lucas
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Amaro, Monique C.
;
de Moraes, Josue
;
Silva, Dulce Helena S.
;
Cito, Antonia Maria das Gracas L.
;
Feitosa, Chistiane Mendes
Total Authors: 13
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| Document type: | Journal article |
| Source: | Journal of Natural Products; v. N/A, p. 7-pg., 2025-01-04. |
| Abstract | |
With praziquantel being the sole available drug for schistosomiasis, identifying novel anthelmintic agents is imperative. A chemical investigation of the fruiting body of the bioluminescent mushroom Neonothopanus gardneri Berk. resulted in the isolation of new conjugated long-chain fatty acids (8E,10E,12S,13S)-12,13-dihydroxy-7-oxo-octadeca-8,10-dienoic acid (1) and (7S,8S,9E,11E)-7,8-dihydroxy-13-oxo-octadeca-9,11-dienoic acid (2) and three previously described compounds, (7R,8R,9Z)-7,8-dihydroxyoctadec-9-enoic acid (3), (2E)-dec-2-ene-1,10-dioic acid (4), and a ketolactone marasmeno-1,15-dione (5). Their planar structures were elucidated based on 1D and 2D NMR and MS/MS spectroscopic analyses. Compound 3 displayed significant antiparasitic activity against Schistosoma mansoni ex vivo (EC50 < 10 mu M). No toxicity was observed in mammalian cells or Caenorhabditis elegans. (AU) | |
| FAPESP's process: | 23/08418-6 - Searching for bioactive metabolites from Brazilian biodiversity as drug candidates for diseases caused by parasitic worms |
| Grantee: | Josué de Moraes |
| Support Opportunities: | Regular Research Grants |