Improving the Biopharmaceutical Properties of Cannabinoids in Glioblastoma Multiforme Therapy With Nanotechnology: A Drug Delivery Perspective

Author(s)

Walker, Stephanie B. ; Duarte, Jonatas L. ; Di Filippo, Leonardo D. ; Chorilli, Marlus

• Document type: Journal article
• Source: Drug Development Research; v. 85, n. 8, p. 12-pg., 2024-12-01.

Abstract

Glioblastoma multiforme (GBM) is the most prevalent primary brain tumor in adults and is known for its rapid proliferation and infiltrative nature. Current therapeutic strategies include surgical resection followed by radio- and chemotherapy. Still, they are hindered by GBM biological characteristics and physical-chemical properties of chemotherapeutic drugs, leading to limited efficacy and poor prognosis. Cannabinoids have emerged as potential anti-GBM agents, exhibiting antiangiogenic, antimetastatic, and antiproliferative effects. However, their hydrophobicity and poor oral bioavailability pose significant challenges for clinical applications. This study evaluates the potential of nanocarriers in enhancing the solubility and targeted delivery of cannabinoids for GBM therapy. The innovative combination of nanotechnology with cannabinoid-based treatment offers a promising strategy to improve therapeutic outcomes. We addressed the application of nanocarriers to deliver cannabinoids, which can enhance passage across the blood-brain barrier and enable targeted therapy. Studies demonstrate the potential of nanocarriers in improving solubility, stability, and controlled release of cannabinoids, highlighting the advancements in nanocarrier design for optimized delivery to glioma cells. Cannabinoids can exert their antitumor effect, including the induction of apoptosis through the ceramide and p8-regulated pathways and the modulation of immune responses. The evidence found in this study supports the potential of cannabinoid-based nanotechnologies in GBM therapeutic regimens as a strategy to enhance its efficacy and patient outcomes. (AU)

• FAPESP's process: 22/11101-1 - Exploring the potential of functionalized nanostructured lipid carriers loaded with cetuximab dispersed in thermo-responsive mucoadhesive hydrogels for the intranasal administration of temozolomide and ellagic acid in the treatment of GBM
• Grantee: Jonatas Lobato Duarte
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 20/12622-0 - Evaluation of the biological potential of nanostructured lipid carriers functionalized with cetuximab dispersed in mucoadhesive thermo-responsive hydrogels for intranasal administration of temozolomide in the treatment of Glioblastoma Multiforme
• Grantee: Leonardo Delello Di Filippo
• Support Opportunities: Scholarships in Brazil - Doctorate