| Full text | |
| Author(s): |
Silva, Rodrigo C.
;
Batista, Gabriel M. F.
;
Brocksom, Timothy J.
;
de Oliveira, Kleber T.
Total Authors: 4
|
| Document type: | Journal article |
| Source: | ADVANCED SYNTHESIS & CATALYSIS; v. N/A, p. 10-pg., 2024-11-20. |
| Abstract | |
Herein, we report a multidimensional screening strategy to discover Electron Donor-Acceptor (EDA) complex photochemical reactions using only simple photographic devices, such as webcams or cellphones, combined with TLC analysis. An algorithm was designed to automatically identify EDA-complex reactive mixtures in solution by processing digital images from a 96-well microplate, alongside TLC results. The code detects the absorption region of the mixture in the visible spectrum and quantifies color changes through grayscale values. Integrated automatic TLC analysis further classifies mixtures as colorimetric reactions, non-reactive, or potentially reactive EDA complexes. Leveraging this screening platform, we have developed a new EDA-mediated approach to synthesize iminophosphoranes in yields up to 90%. (AU) | |
| FAPESP's process: | 18/00879-6 - Arylation reactions of heterocycles photocatalysed by porphyrins in both batch and continuous flow conditions. |
| Grantee: | Rodrigo Costa e Silva |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 23/04020-8 - APIs synthesis using enabling technologies: approaches involving electrosynthesis and photocatalysis under continuous flow conditions |
| Grantee: | Kleber Thiago de Oliveira |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 19/27176-8 - Asymmetric photocatalysis applied to the synthesis of Brivaracetam: synthetic approaches employing enabling technologies for chemical synthesis |
| Grantee: | Kleber Thiago de Oliveira |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 13/07276-1 - CEPOF - Optics and Photonic Research Center |
| Grantee: | Vanderlei Salvador Bagnato |
| Support Opportunities: | Research Grants - Research, Innovation and Dissemination Centers - RIDC |
| FAPESP's process: | 20/06874-6 - Applications of technologies and synthetic methodologies developed under continuous flow conditions at LQBO-UFSCar for the preparation of molecules with biological activities and APIs |
| Grantee: | Kleber Thiago de Oliveira |
| Support Opportunities: | Regular Research Grants |