| Full text | |
| Author(s): |
Ortiz, Alvaro De Jesus Huamani
;
Segura, Anthony Vladimir Campos
;
Bocanegra, Kevin Jorge Magano
;
Sotomayor, Mariana Belen Velasquez
;
Pastor, Heli Jaime Barron
;
de Barron, Yesica Barron Llimpe Mitma
;
Villanueva, Ruy Diego Chacon
;
Carrasco, Alexis German Murillo
;
Rojas, Cesar Alexander Ortiz
Total Authors: 9
|
| Document type: | Journal article |
| Source: | CANCERS; v. 17, n. 3, p. 16-pg., 2025-02-01. |
| Abstract | |
Background/Objectives: Gastric cancer (GC) is a highly aggressive malignancy with diverse molecular subtypes. While microsatellite instability (MSI) GC generally carries a favorable prognosis, a subset of patients experiences poor outcomes, highlighting the need for refined prognostic markers. Methods: This study utilized transcriptomic and clinical data from two independent cohorts, The Cancer Genome Atlas (TCGA) and the Asian Cancer Research Group (ACRG), to identify novel prognostic genes in MSI-GC. Results: Through rigorous survival analysis, we identified high MAP4K4 expression (MAP4K4high) as an independent and robust predictor of poor overall survival (OS) and disease-free survival (DFS) specifically within the MSI-GC subtype. MAP4K4high was associated with increased hazard ratios for both OS and DFS in both cohorts, even after adjusting for clinicopathological factors. Further analysis revealed that MAP4K4high MSI-GC tumors exhibit a distinct molecular profile characterized by increased extracellular matrix remodeling, epithelial-mesenchymal transition, and a microenvironment enriched in monocytes and cancer-associated fibroblasts (CAFs). Notably, a subgroup of MSI-GC patients with a CIN-like phenotype and high MAP4K4 expression exhibited particularly dismal outcomes. Conclusions: Our findings establish MAP4K4 as a promising prognostic biomarker for risk stratification in MSI-GC and suggest its potential role in driving aggressive tumor behavior through modulation of the tumor microenvironment. (AU) | |
| FAPESP's process: | 19/05583-0 - Enrichment of STn/Tn+ tumor-derived extracellular microvesicles for evaluating miRNA-based biomarkers in Breast Cancer patients |
| Grantee: | Alexis Germán Murillo Carrasco |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |
| FAPESP's process: | 17/08430-5 - Detection of TP73 gene transcripts in Acute Promyelocytic Leukemia and their impact in prognosis and therapeutics response |
| Grantee: | César Alexander Ortiz Rojas |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |