7,12-Dimethylbenz(a)anthracene as a Model for Ovarian Cancer Induction in Rats

Author(s)

Goncalves, Ana Carolina Ciseski ; Carvalho, Katia Candido ; Turri, Jose Antonio Orellana ; Simoes, Ricardo dos Santos ; Carvalho, Jesus Paula ; da Silva, Luiz Fernando Ferraz ; Soares Junior, Jose Maria ; Baracat, Edmund Chada

• Document type: Journal article
• Source: BIOLOGY-BASEL; v. 14, n. 1, p. 24-pg., 2025-01-01.

Abstract

Ovarian cancer has the highest mortality rate of all gynecological cancers. Animal models using 7,12-dimethylbenz(a)anthracene (DMBA) have been developed to investigate the mechanisms of ovarian carcinogenesis. The present study is a systematic review of efforts to establish DMBA as a model for ovarian cancer induction in rat models. A total of 432 studies were retrieved from the Medline/PubMed and Embase databases. The studies using DMBA to induce ovarian cancer with isolated results were included in our analysis, and their data were meta-analyzed. The ROBINS-I tool and a meta-analysis demonstrated a low risk of bias (less than 1%) for increased effectiveness and no bias for mortality. The results were all similar: regardless of the dose, administration route, animal strain, or induction time, the induction rate of ovarian tumors was always high, reinforcing the role of DMBA as an effective inducer of ovarian carcinogenesis. We conclude that ovarian carcinogenesis can be studied using DMBA as an inducer in rat and mouse models with a long time range for tumor establishment (at least 110 days) and a high rate of mortality. CNPq (No. 304264/2021-0) and FAPESP (Protocol No. 2018/24224-9). (AU)

• FAPESP's process: 18/24224-9 - Extra reproductive effects of melatonin on the genital system and breast
• Grantee: José Maria Soares Junior
• Support Opportunities: Research Projects - Thematic Grants