Physical exercise-mediated neuroprotective mechanisms in Parkinson's disease, Alzheimer's disease, and epilepsy

Author(s)

Pinho, R. A. ; Muller, A. P. ; Marqueze, L. F. ; Radak, Z. ; Arida, R. M.

• Document type: Journal article
• Source: Brazilian Journal of Medical and Biological Research; v. 57, p. 12-pg., 2024-01-01.

Abstract

Research suggests that physical exercise is associated with prevention and management of chronic diseases. The influence of physical exercise on brain function and metabolism and the mechanisms involved are well documented in the literature. This review provides a comprehensive overview of the potential implications of physical exercise and the molecular benefits of exercise in Parkinson's disease, Alzheimer's disease, and epilepsy. Here, we present an overview of the effects of exercise on various aspects of metabolism and brain function. To this end, we conducted an extensive literature search of the PubMed, Web of Science, and Google Scholar databases to identify articles published in the past two decades. This review delves into key aspects including the modulation of neuroinflammation, neurotrophic factors, and synaptic plasticity. Moreover, we explored the potential role of exercise in advancing therapeutic strategies for these chronic diseases. In conclusion, the review highlights the importance of regular physical exercise as a complementary non-pharmacological treatment for individuals with neurological disorders such as Alzheimer's, Parkinson's disease, and epilepsy. (AU)

• FAPESP's process: 22/10696-1 - Study of morphophysiological changes in the brain of rats submitted to a physical exercise program throughout life and during aging
• Grantee: Ricardo Mario Arida
• Support Opportunities: Regular Research Grants