Carbon dioxide redox metabolites in oxidative eustress and oxidative distress

Author(s)

Augusto, Ohara ; Truzzi, Daniela Ramos

• Document type: Journal article
• Source: BIOPHYSICAL REVIEWS; v. 13, n. 6, p. 3-pg., 2021-12-01.

Abstract

High carbon dioxide tensions (hypercapnia) are toxic to mammals by both pH-dependent and pH-independent mechanisms that remain partially understood. Relevantly, carbon dioxide reacts with biologically ubiquitous oxygen metabolites such as peroxynitrite and hydrogen peroxide to produce carbonate radical and peroxymonocarbonate, respectively. These metabolites are redox active making it timely to discuss the potential role of carbon dioxide redox metabolites in oxidative eustress and oxidative distress conditions. (AU)

• FAPESP's process: 19/17483-0 - Dinitrosyl iron complexes (DNICs): formation, reactivity, and implications for the physiopathology of nitric oxide
• Grantee: Daniela Ramos Truzzi
• Support Opportunities: Research Grants - Young Investigators Grants
• FAPESP's process: 13/07937-8 - Redoxome - Redox Processes in Biomedicine
• Grantee: Ohara Augusto
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC