Effect of a lifestyle intervention among pregnant women with overweight on neonatal adiposity: A randomized controlled clinical trial

Author(s)

Baroni, Naiara Franco ; Carvalho, Mariana Rinaldi ; Santos, Izabela da Silva ; Chaves, Ana Vitoria Lanzoni ; Miranda, Daniela Elias Goulart de Andrade ; Crivellenti, Livia Castro ; Sartorelli, Daniela Saes

• Document type: Journal article
• Source: EARLY HUMAN DEVELOPMENT; v. 194, p. 8-pg., 2024-05-21.

Abstract

Background: The excess neonatal adiposity is considered a risk factor for the development of childhood obesity and the birth weight is a marker of health throughout life. Aims: To evaluate the effect of a lifestyle intervention conducted among pregnant women with overweight on neonatal adiposity and birth weight. Methods: A total of 350 pregnant women were recruited and randomly allocated into the control (CG) and intervention (IG) groups. Pregnant women in the IG were invited to participate in three nutritional counselling sessions based on encouraging the consumption of unprocessed and minimally processed foods, rather than ultra- processed foods, following the NOVA food classification system, which categorizes foods according to the extent and purpose of industrial processing, and the regular practice of physical activity. Neonatal adiposity was estimated using a previously validated anthropometric model. Adjusted linear regression models were used to measure the effect. Results: Adopting the modified intention-to-treat principle, data from 256 neonates were analyzed for birth weight, and data from 163 for body composition estimation. The treatment had no effect on the proportion of fat mass [(3 0.52 (95 % CI-1.03, 2.06); p = .51], fat-free mass [(3-0.50 (95 % CI-2.45, 1.45); p = .61] or birth weight [(3 53.23 (95 % CI-87.19, 193.64); p = .46]. Conclusions: In the present study, the lifestyle counselling used had no effect on neonatal adiposity or birth weight. Future studies should investigate the effect of more intensive interventions. (AU)

• FAPESP's process: 17/15386-2 - Nutritional intervention study in overweight pregnant women attending primary healthcare units: a randomized clinical trial.
• Grantee: Daniela Saes Sartorelli
• Support Opportunities: Regular Research Grants
• FAPESP's process: 17/18980-2 - Adherence to the goals of a lifestyle intervention among overweight pregnant women and its effect on perinatal outcomes
• Grantee: Lívia Castro Crivellenti
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 21/06486-9 - Impact of a nutritional intervention in overweight pregnant women on child growth and development at six months
• Grantee: Izabela da Silva Santos
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 21/06586-3 - Relationship between the paternal characteristics and child anthropometry from birth to the first year of life in a clinical trial of nutritional intervention
• Grantee: Mariana Rinaldi Carvalho
• Support Opportunities: Scholarships in Brazil - Doctorate