What we have learned from non-human primates as animal models of epilepsy

Author(s)

Sanabria, Viviam ; Romariz, Simone A. A. ; Braga, Matheus ; Pires, Jaime Moreira ; Naffah-Mazzacoratti, Maria da Graca ; Mello, Luiz Eugenio ; Longo, Beatriz M. ; Foresti, Maira Licia

• Document type: Journal article
• Source: Epilepsy & Behavior; v. 154, p. 10-pg., 2024-03-21.

Abstract

Non -human primates (NHPs) have played a crucial role in our understanding of epilepsy, given their striking similarities with humans. Through their use, we have gained a deeper understanding of the neurophysiology and pathophysiology of epileptic seizures, and they have proven invaluable allies in developing anti -seizure therapies. This review explores the history of NHPs as natural models of epilepsy, discusses the findings obtained after exposure to various chemoconvulsant drugs and focal electrical stimulation protocols that helped uncover important mechanisms related to epilepsy, examines diverse treatments to prevent and manage epilepsy, and addresses essential ethical issues in research. In this review, we aim to emphasize the important role of NHPs in epilepsy research and summarize the benefits and challenges associated with their use as models. (AU)

• FAPESP's process: 18/24561-5 - Epileptogenesis, biomarkers and post-traumatic epilepsy
• Grantee: Luiz Eugenio Araujo de Moraes Mello
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 17/05242-3 - STUDY OF THE ANTICONVULSANT EFFECT OF CANNABIDIOL AFTER TRAUMATIC BRAIN INJURY.
• Grantee: Simone Amaro Alves Romariz Bertola
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 22/00249-8 - Evaluation of the effects of resistance exercise and induction of amyloidogenesis and neuroinflammation in in vivo and in vitro models of Alzheimer's Disease
• Grantee: Beatriz de Oliveira Monteiro
• Support Opportunities: Regular Research Grants