| Full text | |
| Author(s): Show less - |
Guzzoni, Vinicius
;
de Abreu, Isabel Cristina Mallosto Emerich
;
Bertagnolli, Mariane
;
Mendes, Roberta Hack
;
Bello-Klein, Adriane
;
Casarini, Dulce Elena
;
Flues, Karin
;
Candido, Georgia Orsi
;
Paulini, Janaina
;
De Angelis, Katia
;
Marcondes, Fernanda Klein
;
Irigoyen, Maria Claudia
;
Sousa Cunha, Tatiana
Total Authors: 13
|
| Document type: | Journal article |
| Source: | ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY; v. 130, n. 6, p. 13-pg., 2024-07-17. |
| Abstract | |
ObjectveThe purpose of the research was to investigate the effects of aerobic training on renal function, oxidative stress, intrarenal renin-angiotensin system, and mortality of hypertensive and diabetic (SHR-STZ) rats.Materials and MethodsBlood pressure, creatinine, urea levels, urinary glucose, urine volume, and protein excretion were reduced in trained SHR-STZ rats.ResultsAerobic training not only attenuated oxidative stress but also elevated the activity of antioxidant enzymes in the kid ' ney of SHR-STZ rats. Training increased intrarenal levels of angiotensin-converting enzymes (ACE and ACE2) as well as the neprilysin (NEP) activity, along with decreased intrarenal angiotensin II (Ang II) levels. Aerobic training significantly improved the survival of STZ-SHR rats.ConclusionThe protective role of aerobic training was associated with improvements in the renal antioxidative capacity, reduced urinary protein excretion along with reduced intrarenal Ang II and increased NEP activity. These findings might reflect a better survival under the combined pathological conditions, hypertension, and diabetes. (AU) | |
| FAPESP's process: | 10/51904-9 - Renin angiotensin and kallikrein kinin systems in hypertension, obesity, diabetes, desnutrition and sepsis: molecular, cellular and physiopathologic mechanisms |
| Grantee: | Dulce Elena Casarini |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 21/06090-8 - Role of endurance training on chronic stress-induced cardiac hypertrophy: involvement of the renin angiotensin system, JNK and p38 MAPK signaling pathways |
| Grantee: | Vinicius Guzzoni |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |