VaxGO: an interactive web tool for systems vaccinology data analysis

Author(s):Show less -

Prates-Syed, Wasim Aluisio ; Lima, Aline Aparecida ; Cortes, Nelson ; Carvalho, Evelyn ; Silva, Jaqueline Dinis Queiroz ; Hamaguchi, Barbara ; Duraes-Carvalho, Ricardo ; Cabral-Marques, Otavio ; Hagan, Thomas ; Krieger, Jose E. ; Cabral-Miranda, Gustavo

• Document type: Journal article
• Source: BIOINFORMATICS ADVANCES; v. 5, n. 1, p. 5-pg., 2025-01-01.

Abstract

Motivation RNA sequencing is crucial for investigating transcriptional patterns in immunology and vaccine research. However, the analysis of RNA sequencing data often requires programming skills, which can limit accessibility for researchers lacking such expertise.Results We present VaxGO, an intuitive web-based tool designed to facilitate the analysis of differentially expressed genes in the context of immune processes and cells during vaccination. This tool integrates data from Gene Ontology, CellMarker 2.0, the MSigDB Vax collection, and other key studies, including transcriptional atlases of vaccines against COVID-19 and other diseases. VaxGO is an interactive, web-based tool, offering a user-friendly platform for exploring immune responses and vaccine efficacy without programming expertise.Availability and implementation The VaxGO tool is available at https://github.com/wapsyed/VaxGO. (AU)

• FAPESP's process: 25/01063-3 - A Systems Vaccinology Study Between Humans and Animal Models for Translational Medicine
• Grantee: Wasim Aluísio Prates Syed
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate (Direct)
• FAPESP's process: 19/14526-0 - Development of vaccines against Streptococcus pyogenes and Chikungunya Virus based on virus like particles
• Grantee: Gustavo Cabral de Miranda
• Support Opportunities: Research Grants - Young Investigators Grants
• FAPESP's process: 21/08468-8 - Development of VLPs-based vaccines against SARS-CoV-2 and other human Coronaviruses
• Grantee: Wasim Aluísio Prates Syed
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• FAPESP's process: 20/05146-7 - Development of vaccine anti-SARS-CoV-2 based on VLPs
• Grantee: Gustavo Cabral de Miranda
• Support Opportunities: Regular Research Grants