Neuroprotection provided by polyphenols and flavonoids in photoreceptor degenerative diseases

Author(s)

de Lima-Vasconcellos, Theo Henrique ; Bovi dos Santos, Gabrieli ; Movio, Marilia Ines ; Donnici, Giovanna Klemenc ; Badin, Gabriela Maria ; de Araujo, Daniele Ribeiro ; Kihara, Alexandre Hiroaki

• Document type: Journal article
• Source: NEURAL REGENERATION RESEARCH; v. 21, n. 3, p. 15-pg., 2026-03-01.

Abstract

The intricate landscape of neurodegenerative diseases complicates the search for effective therapeutic approaches. Photoreceptor degeneration, the common endpoint in various retinal diseases, including retinitis pigmentosa and age-related macular degeneration, leads to vision loss or blindness. While primary cell death is driven by genetic mutations, oxidative stress, and neuroinflammation, additional mechanisms contribute to disease progression. In retinitis pigmentosa, a multitude of genetic alterations can trigger the degeneration of photoreceptors, while other retinopathies, such as age-related macular degeneration, are initiated by combinations of environmental factors, such as diet, smoking, and hypertension, with genetic predispositions. Nutraceutical therapies, which blend the principles of nutrition and pharmaceuticals, aim to harness the health benefits of bioactive compounds for therapeutic applications. These compounds generally possess multi-target effects. Polyphenols and flavonoids, secondary plant metabolites abundant in plant-based foods, are known for their antioxidant, neuroprotective, and anti-inflammatory properties. This review focuses on the potential of polyphenols and flavonoids as nutraceuticals to treat neurodegenerative diseases such as retinitis pigmentosa. Furthermore, the importance of developing reliable delivery methods to enhance the bioavailability and therapeutic efficacy of these compounds will be discussed. By combining nutraceuticals with other emerging therapies, such as genetic and cell-based treatments, it is possible to offer a more comprehensive approach to treating retinal degenerative diseases. These advancements could lead to a viable and accessible option, improving the quality of life for patients with retinal diseases. (AU)

• FAPESP's process: 24/00828-3 - Utilizing flavonoids for the treatment of autosomal recessive retinitis pigmentosa: a nutraceutical approach
• Grantee: Théo Henrique de Lima Vasconcellos
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 24/10858-7 - Nutraceutical therapy: the effect of rutin on reactive gliosis in retinitis pigmentosa.
• Grantee: Gabriela Maria Badin Correa
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• FAPESP's process: 20/11667-0 - Cellular and electrophysiological changes in the hippocampus caused by neurodegenerative processes related to neonatal anoxia and temporal lobe epilepsy
• Grantee: Alexandre Hiroaki Kihara
• Support Opportunities: Regular Research Grants
• FAPESP's process: 21/11969-9 - The role of IP3R1 in neuroinflammation triggered by retinitis pigmentosa
• Grantee: Théo Henrique de Lima Vasconcellos
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 21/14227-3 - ESTABLISHMENT OF A 3D IN VITRO MODEL OF RETINITIS PIGMENTOSA
• Grantee: Gabrieli Bovi dos Santos
• Support Opportunities: Scholarships in Brazil - Master