Metachronous colorectal cancer risks after extended or segmental resection in MLH1, MSH2, and MSH6 Lynch syndrome: multicentre study from the Prospective Lynch Syndrome Database

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Zalevskaja, K. ; Ojala, K. ; Petrov, A. ; Haupt, S. ; Sunde, L. ; Bernstein, I ; Jenkins, M. A. ; Aretz, S. ; Nielsen, M. ; Capella, G. ; Balaguer, F. ; Evans, D. G. ; Burn, J. ; Holinski-Feder, E. ; Bertario, L. ; Bonanni, B. ; Lindblom, A. ; Levi, Z. ; Macrae, F. ; Winship, I ; Plazzer, J-P ; Sijmons, R. ; Laghi, L. ; Della Valle, A. ; Heinimann, K. ; Debniak, T. ; Fruscio, R. ; Lopez-Koestner, F. ; Alvarez-Valenzuela, K. ; Katz, L. H. ; Laish, I ; Vainer, E. ; Vaccaro, C. ; Carraro, D. M. ; Monahan, K. ; Half, E. ; Stakelum, A. ; Winter, D. ; Kennelly, R. ; Gluck, N. ; Sheth, H. ; Abu-Freha, N. ; Greenblatt, M. ; Rossi, B. M. ; Bohorquez, M. ; Cavestro, G. M. ; Lino-Silva, L. S. ; Horisberger, K. ; Tibiletti, M. G. ; do Nascimento, I ; Thomas, H. ; Rossi, N. T. ; da Silva, L. A. ; Zarand, A. ; Ruiz-Banobre, J. ; Heuveline, V ; Lindberg, L. J. ; Gogenur, I ; Hopper, J. L. ; Win, A. K. ; Haile, R. W. ; Lindor, N. ; Gallinger, S. ; Le Marchand, L. ; Newcomb, P. A. ; Figueiredo, J. ; Buchanan, D. D. ; Thibodeau, S. N. ; Knebel Doeberitz, M., V ; Loeffler, M. ; Rahner, N. ; Schroeck, E. ; Steinke-Lange, V ; Schmiegel, W. ; Vangala, D. ; Perne, C. ; Hueneburg, R. ; Redler, S. ; Buettner, R. ; Weitz, J. ; Pineda, M. ; Duenas, N. ; Brunet Vidal, J. ; Moreira, L. ; Sanchez, A. ; Castillo-Iturra, J. ; Hovig, E. ; Green, K. ; Lalloo, F. ; Hill, J. ; Crosbie, E. ; Mints, M. ; Goldberg, Y. ; Tjandra, D. ; ten Broeke, S. W. ; Kariv, R. ; Rosner, G. ; Jain, A. ; Shah, P. ; Shah, M. ; Neffa, F. ; Esperon, P. ; Pavicic, W. ; Torrezan, G. T. ; Bassaneze, T. ; Martin, C. A. ; Pylvanainen, K. ; Moeslein, G. ; Lepistoe, A. ; Mecklin, J-P ; Renkonen-Sinisalo, L. ; Sampson, J. R. ; Dominguez Valentin, M. ; Moller, P. ; Seppala, T. T.

• Document type: Journal article
• Source: BRITISH JOURNAL OF SURGERY; v. 112, n. 4, p. 11-pg., 2025-04-01.

Abstract

This first prospective observational study evaluates the impact of extended versus segmental colorectal surgery on the risk of metachronous colorectal cancer (CRC) in patients with Lynch syndrome, analyzing data from the Prospective Lynch Syndrome Database version 5. Extended resection significantly reduced the risk of metachronous CRC in path_MLH1, path_MSH2, and path_MSH6 carriers compared to segmental resection. (AU)

• FAPESP's process: 14/50943-1 - INCT 2014: on Oncogenomics and Therapeutic Inovations
• Grantee: Dirce Maria Carraro
• Support Opportunities: Research Projects - Thematic Grants