| Full text | |
| Author(s): Show less - |
Bariani, Bruna
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Pinto, Bianca S.
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Santos, Leonardo A.
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Benatti, Rafael G.
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Lessa, Maira M. P.
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Loureiro, Julia C.
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Silva, Jessica F.
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Silva, Valquiria A.
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Cardeal, Henriette B.
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Pereira, Jefferson L.
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Miranda, Cristiane S.
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Forlenza, Orestes Vicente
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Leao, Caroline S.
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Ruiz, Francisco J.
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Brunoni, Andre R.
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Valiengo, Leandro
Total Authors: 16
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| Document type: | Journal article |
| Source: | Journal of Affective Disorders; v. 393, p. 9-pg., 2026-01-15. |
| Abstract | |
Background: Major depressive disorder (MDD) is one of the leading causes of disability, especially among elderly. Repetitive transcranial magnetic stimulation (rTMS) is an effective non-pharmacological treatment and theta burst stimulation (TBS) technique offers shorter sessions. Acceptance and Commitment Therapy (ACT) is a proven effective intervention in the treatment of MDD. However, to date, no studies have evaluated the combination of rTMS and ACT in geriatric depression. Objective: Investigate if the addition of a four-week ACT-based intervention to TBS could possibly enhance the effectiveness of the treatment for elderly adults suffering from MDD. Design, setting, and participants: A double-blind, sham-controlled RCT was performed in the University of S & atilde;o Paulo (2021-2024) with a total of 29 subjects, >= 60 years of age, with MDD and HDRS >16. Intervention: Patients received TBS during the first 20 days, with supplementary sessions at weeks 6, 8, and 12. ACT group attended four weekly 60-min ACT sessions, while the control group had support sessions. Results: ACT group showed faster response in the MDD symptoms: lower HDRS scores at week 6 (p = 0.007). However, the difference was not sustained in weeks 8 (p = 0.111) and 12 (p = 0.307). In week 6 the percentage of remissions in the ACT group (56.3 %) was significantly higher as compared to the control group (15.4 %; p = 0.024). Conclusion: ACT together with TBS facilitated treatment of symptoms faster in the case of old-age MDD, although the long-term disparity was not maintained. Other studies have to be conducted. (AU) | |
| FAPESP's process: | 22/02539-3 - Effect of a brief and focal protocol of Acceptance and Commitment Therapy (ACT) in patients with depression undergoing repetitive transcranial magnetic stimulation by the Theta-burst method: clinical trial, randomized, evaluator blinded, controlled |
| Grantee: | Bruna Bariani Teixeira |
| Support Opportunities: | Scholarships in Brazil - Doctorate |