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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Improved Endothelial Function and Reversal of Myocardial Perfusion Defects after Aerobic Physical Training in a Patient with Microvascular Myocardial Ischemia

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Author(s):
Vieira Carvalho, Eduardo Elias ; Crescencio, Julio Cesar ; Elias, Jr., Jorge ; Alves Brito, Laura Beatriz ; Gallo, Jr., Lourenco ; Simoes, Marcus Vinicius [1]
Total Authors: 6
Affiliation:
[1] Univ Sao Paulo, Dept Internal Med, Div Cardiol, Sch Med Ribeirao Preto, Fac Med Ribeirao Preto, Sao Paulo - Brazil
Total Affiliations: 1
Document type: Journal article
Source: AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION; v. 90, n. 1, p. 59-64, JAN 2011.
Web of Science Citations: 5
Abstract

The objective of this report is to document the effects of an aerobic training program on myocardial perfusion, and endothelial function abnormalities, and on the relief of angina in a patient with microvascular myocardial ischemia. A 53-year-old female patient exhibited precordial pain on effort and angiographically normal coronaries. Her symptoms had been present for 4 yrs despite pharmacologic treatment for the control of risk factors, with myocardial perfusion scintigraphy revealing an extensive reversible perfusion defect. She was submitted to aerobic training for 4 mos, obtaining significant improvement of the anginal symptoms. Additionally, after the aerobic training program, scintigraphy revealed the disappearance of the myocardial perfusion defect, with a marked improvement of endothelium-dependent vasodilatory response and an improved quality-of-life score. These results suggest that aerobic training can improve endothelial function, leading to a reduction of ischemia and an improved quality-of-life in patients with microvascular myocardial ischemia. (AU)

FAPESP's process: 08/04140-3 - Study of the correlation between the extent of myocardial sympathetic denervation and arrhythmic events in patients with chronic Chagas cardiomyopathy
Grantee:Marcus Vinicius Simões
Support type: Regular Research Grants