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(Reference retrieved automatically from Google Scholar through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Kallikrein kinin system activation in post-exercise hypotension in water running of hypertensive volunteers

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Author(s):
Pontes Jr‚ F.L. ; Bacurau‚ R.F.P. ; Moraes‚ M.R. ; Navarro‚ F. ; Casarini‚ D.E. ; Pesquero‚ J.L. ; Pesquero‚ J.B. ; Araújo‚ R.C. ; Piçarro‚ I.C.
Total Authors: 9
Document type: Journal article
Source: International Immunopharmacology; v. 8, n. 2, p. 261-266, 2008.
Abstract

Previous studies demonstrated a reduction in blood pressure level immediately after different types of exercises, like running, cycling and resistance training, a phenomenon called post-exercise hypotension (PEH). Since PEH can persist for hours it could be suggested as a non-pharmacological therapy for hypertensive individuals. Unfortunately, usually running is not recommended due to the high impact caused by its practice. Therefore running in water treadmill should be a better option, since the environment is completely different and causes lower impact. However it is not known whether PEH occurs in this situation. The objective of this work was to evaluate the existence of PEH after water running and to compare PEH promoted by running in two different environments. In addition, changes in plasmatic concentrations of the kallikrein kinin system (KKS) components were also evaluated. Sixteen hypertensive subjects were submitted to two exercise sessions, conventional running and water running, in two different occasions. The pattern of heart rate, blood pressure and plasmatic concentrations of KKS components immediately after and one hour after exercise were investigated. Results showed a maximal reduction in systolic and diastolic blood pressure 30 min after both exercise models (P<0.001), indicating that moderate water running promotes PEH with similar magnitude as compared to conventional running. Plasma kallikrein activity and bradykinin concentration increased immediately after exercise (P<0.05), but these parameters were not different in both exercise models. In conclusion, our findings show that water running, similarly to conventional running, can also provoke PEH and alterations in the KKS components. (c) 2007 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 01/07538-9 - Structural Genomics Program
Grantee:Ronaldo de Carvalho Araújo
Support Opportunities: Regular Research Grants