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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Pre-emptive epidural injection of xylazine or amitraz, in horses: antinociceptive effect

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Author(s):
Guirro, Erica Cristina Bueno do Prado [1] ; Roberto Sobrinho, Guilherme ; Ferreira, Isabella Maria Marchesini ; Valadão, Carlos Augusto Araújo
Total Authors: 4
Affiliation:
[1] Universidade Estadual Paulista (UNESP). Campus de Jaboticabal. Faculdade de Ciências Agrárias e Veterinárias - Brasil
Total Affiliations: 4
Document type: Journal article
Source: Ciência Rural; v. 39, n. 1, p. 104-109, 2009.
Field of knowledge: Agronomical Sciences - Veterinary Medicine
Abstract

Epidural administration of ALPHA-2 agonists promotes antinociceptive effect and amitraz acts on ALPHA-2 receptors. Antinociceptivo effect caused by pre-emptive epidural injection of 0.17mg kg-1 xylazine (GX) or 0.1mg kg-1 amitraz diluted in lipidic emulsion (GA) were evaluated, in 12 horses submitted by incisional model of inflammatory pain and evaluated about nociceptive threshold by mechanical stimulus (NTMS), by von Frey filaments. Xylazine produced maintenance of NTMS for 4 hours, while amitraz diluted in lipidic solution maintained NTMS for 24 hours. (AU)