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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

High prevalence of hepatitis B virus subgenotypes A1 and D4 in Maranhao state, Northeast Brazil

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Fonseca Barros, Lena Maria [1] ; Gomes-Gouvea, Michele Soares [2, 3] ; Kramvis, Anna [4] ; Jacintho Mendes-Correa, Maria Cassia [5] ; dos Santos, Alexsandro [1] ; Barros Souza, Leticia Alana [1] ; Cruz Santos, Max Diego [1] ; Carrilho, Flair Jose [2, 3] ; Domicini, Arnaldo de Jesus [1] ; Rebello Pinho, Joao Renato [2, 3] ; Paiva Ferreira, Adalgisa de Souza [1]
Total Authors: 11
[1] Univ Fed Maranhao, Sao Luis, Maranhao - Brazil
[2] Univ Sao Paulo, Sch Med, Lab Gastroenterol & Hepatol, Sao Paulo Inst Trop Med, Sao Paulo - Brazil
[3] Univ Sao Paulo, Sch Med, Dept Gastroenterol, Sao Paulo - Brazil
[4] Univ Witwatersrand, Sch Clin Med, Dept Internal Med, Hepatitis Virus Div Res Programme, Johannesburg - South Africa
[5] Univ Sao Paulo, Sch Med, Dept Infect Dis, Sao Paulo - Brazil
Total Affiliations: 5
Document type: Journal article
Source: INFECTION GENETICS AND EVOLUTION; v. 24, p. 68-75, JUN 2014.
Web of Science Citations: 16

In this study, we determined the prevalence of HBV subgenotypes in Maranhao state, located in northeastern Brazil, where the population is heterogeneous, with a high proportion of African descendants. HBV was detected in 119 of 133 (89.5%) chronic hepatitis B patients, including 103 (86.5%) who were HBeAg-negative. Using phylogenetic analysis of the S/Polymerase region of HBV DNA, subgenotype A1 was found to be the most prevalent (67%), followed by genotype D (28%; subgenotype D4 was detected in 24%, D3 in 3%, and D2 in 1%). Genotype F, clustering with subgenotype F2a, was found in six (5%) patients. The topology of the phylogenetic tree showed that HBV/A1 sequences did not cluster together, suggesting that more than one strain was introduced into Maranhao. On the other hand, HBV/D4 sequences formed a monophyletic cluster, suggesting a single entry of this strain in this population. This study showed that HBV/A1 was the only subgenotype of HBV/A present in the population from Maranhao and indicated that in this region HBV/A1 was not restricted to an Afro-descendant community where it was previously reported, but is widely distributed among general population of HBV chronic carriers. Unexpectedly, we found a high frequency of HBV subgenotype D4. Together with previously reported data on the distribution of HBV/D4 in the world, these findings suggest that this subgenotype was more prevalent in the African continent in the past and may have been introduced in Maranhao by means of the slave trade during the late XVIII century, when the largest number of African slaves arrived to this region. (C) 2014 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 10/51208-2 - Prevalence of primary resistance to antiviral therapy against hepatitis B in patients with chronic hepatitis B virus infection and not submitted to treatment
Grantee:Maria Cássia Jacintho Mendes Corrêa
Support Opportunities: Regular Research Grants
FAPESP's process: 10/50081-9 - Prevalence of primary resistance to antiviral therapy against hepatitis B in patients with chronic hepatitis B virus infection and not submitted to treatment
Grantee:Michele Soares Gomes Gouvêa
Support Opportunities: Scholarships in Brazil - Doctorate