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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Diuron-induced rat urinary bladder carcinogenesis: Mode of action and human relevance evaluations using the International Programme on Chemical Safety framework

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Da Rocha, Mitscheli Sanches [1, 2] ; Arnold, Lora L. [1] ; Cotrim Sartor De Oliveira, Maria Luiza [2] ; Ihlaseh Catalano, Shadia M. [2, 3] ; Ferragut Cardoso, Ana Paula [2] ; Pontes, Merielen G. N. [2] ; Ferrucio, Bianca [2] ; Dodmane, Puttappa R. [1] ; Cohen, Samuel M. [1] ; De Camargo, Joao Lauro V. [2]
Total Authors: 10
[1] Univ Nebraska Med Ctr, Omaha, NE - USA
[2] Sao Paulo State Univ UNESP, Dept Pathol, Botucatu Med Sch, Ctr Evaluat Environm Impact Human Hlth TOXICAM, BR-18618970 Sao Paulo - Brazil
[3] BASF, Sao Paulo - Brazil
Total Affiliations: 3
Document type: Review article
Source: CRITICAL REVIEWS IN TOXICOLOGY; v. 44, n. 5, p. 393-406, MAY 2014.
Web of Science Citations: 5

Diuron, a high volume substituted urea herbicide, induced high incidences of urinary bladder carcinomas and low incidences of kidney pelvis papillomas and carcinomas in rats exposed to high doses (2500 ppm) in a 2-year bioassay. Diuron is registered for both occupational and residential uses and is used worldwide for more than 30 different crops. The proposed rat urothelial mode of action (MOA) for this herbicide consists of metabolic activation to metabolites that are excreted and concentrated in the urine, leading to cytotoxicity, urothelial cell necrosis and exfoliation, regenerative hyperplasia, and eventually tumors. We show evidence for this MOA for diuron using the International Programme on Chemical Safety (IPCS) conceptual framework for evaluating an MOA for chemical carcinogens, and the United States Environmental Protection Agency (USEPA) and IPCS framework for assessing human relevance. (AU)

FAPESP's process: 06/60506-1 - Agriculture pesticides as risk factor: toxicologic pathology, immunology, and molecular and analytical evaluations in experimental models of single or combined exposures
Grantee:João Lauro Viana de Camargo
Support type: Research Projects - Thematic Grants
FAPESP's process: 09/02754-7 - Gene expression profiling in the urothelium of male Wistar rats exposed to the herbicide Diuron (3-(3,4-dichlorophenyl)-1,1-dimethylurea)
Grantee:João Lauro Viana de Camargo
Support type: Regular Research Grants