The selective and non-selective cyclooxygenase inh... - BV FAPESP
Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The selective and non-selective cyclooxygenase inhibitors valdecoxib and piroxicam induce the same postoperative analgesia and control of trismus and swelling after lower third molar removal

Full text
Author(s):
Show less -
V. Benetello [1] ; F.C. Sakamoto [2] ; F.P.M. Giglio [3] ; V.T. Sakai [4] ; A.M. Calvo [5] ; K.C.S. Modena [6] ; B.L. Colombini [7] ; T.J. Dionísio [8] ; J.R.P. Lauris [9] ; F.A.C. Faria [10] ; C.F. Santos [11]
Total Authors: 11
Affiliation:
Show less -
[1] Universidade de São Paulo. Faculdade de Odontologia de Bauru. Departamento de Ciências Biológicas
[2] Universidade de São Paulo. Faculdade de Odontologia de Bauru. Departamento de Ciências Biológicas
[3] Universidade de São Paulo. Faculdade de Odontologia de Bauru. Departamento de Ciências Biológicas
[4] Universidade de São Paulo. Faculdade de Odontologia de Bauru. Departamento de Odontopediatria, Ortodontia e Saúde Coletiva - Brasil
[5] Universidade de São Paulo. Faculdade de Odontologia de Bauru. Departamento de Ciências Biológicas
[6] Universidade de São Paulo. Faculdade de Odontologia de Bauru. Departamento de Ciências Biológicas
[7] Universidade de São Paulo. Faculdade de Odontologia de Bauru. Departamento de Ciências Biológicas
[8] Universidade de São Paulo. Faculdade de Odontologia de Bauru. Departamento de Ciências Biológicas
[9] Universidade de São Paulo. Faculdade de Odontologia de Bauru. Departamento de Odontopediatria, Ortodontia e Saúde Coletiva - Brasil
[10] Universidade de São Paulo. Faculdade de Odontologia de Bauru. Departamento de Ciências Biológicas
[11] Universidade de São Paulo. Faculdade de Odontologia de Bauru. Departamento de Ciências Biológicas
Total Affiliations: 11
Document type: Journal article
Source: Brazilian Journal of Medical and Biological Research; v. 40, n. 8, p. 1133-1140, 2007-06-04.
Abstract

We compared the clinical efficacy of orally administered valdecoxib and piroxicam for the prevention of pain, trismus and swelling after removal of horizontally and totally intrabony impacted lower third molars. Twenty-five patients were scheduled to undergo removal of symmetrically positioned lower third molars in two separate appointments. Valdecoxib (40 mg) or piroxicam (20 mg) was administered in a double-blind, randomized and crossed manner for 4 days after the surgical procedures. Objective and subjective parameters were recorded for comparison of postoperative courses. Both agents were effective for postoperative pain relief (N = 19). There was a similar mouth opening at suture removal compared with the preoperative values (86.14 ± 4.36 and 93.12 ± 3.70% of the initial measure for valdecoxib and piroxicam, respectively; ANOVA). There was no significant difference regarding the total amount of rescue medication taken by the patients treated with valdecoxib or piroxicam (173.08 ± 91.21 and 461.54 ± 199.85 mg, respectively; Wilcoxon test). There were no significant differences concerning the swelling observed on the second postoperative day compared to baseline measures (6.15 ± 1.84 and 8.46 ± 2.04 mm for valdecoxib and piroxicam, respectively; ANOVA) or on the seventh postoperative day (1.69 ± 1.61 and 2.23 ± 2.09 mm for valdecoxib and piroxicam, respectively; ANOVA). The cyclooxygenase-2 selective inhibitor valdecoxib is as effective as the non-selective cyclooxygenase inhibitor piroxicam for pain, trismus and swelling control after removal of horizontally and totally intrabony impacted lower third molars. (AU)

FAPESP's process: 07/02946-8 - Valdecoxib and piroxicam efficacy in postoperative analgesia, trismus and swelling control for lower third molar removal: a double-blind, randomized, crossover study
Grantee:Carlos Ferreira dos Santos
Support Opportunities: Regular Research Grants - Publications - Scientific article