| Texto completo | |
| Autor(es): |
Lacoste, Baptiste
[1]
;
Comin, Cesar H.
[2]
;
Ben-Zvi, Ayal
[1]
;
Kaeser, Pascal S.
[1]
;
Xu, Xiaoyin
[3]
;
Costa, Luciano da F.
[2]
;
Gu, Chenghua
[1]
Número total de Autores: 7
|
| Afiliação do(s) autor(es): | [1] Harvard Univ, Sch Med, Dept Neurobiol, Boston, MA 02115 - USA
[2] Univ Sao Paulo, IFSC, Sao Carlos, SP - Brazil
[3] Brigham & Womens Hosp, Dept Radiol, Boston, MA 02115 - USA
Número total de Afiliações: 3
|
| Tipo de documento: | Artigo Científico |
| Fonte: | NEURON; v. 83, n. 5, p. 1117-1130, SEP 3 2014. |
| Citações Web of Science: | 37 |
| Resumo | |
Neurovascular interactions are essential for proper brain function. While the effect of neural activity on cerebral blood flow has been extensively studied, whether or not neural activity influences vascular patterning remains elusive. Here, we demonstrate that neural activity promotes the formation of vascular networks in the early postnatal mouse barrel cortex. Using a combination of genetics, imaging, and computational tools to allow simultaneous analysis of neuronal and vascular components, we found that vascular density and branching were decreased in the barrel cortex when sensory input was reduced by either a complete deafferentation, a genetic impairment of neurotransmitter release at thalamocortical synapses, or a selective reduction of sensory-related neural activity by whisker plucking. In contrast, enhancement of neural activity by whisker stimulation led to an increase in vascular density and branching. The finding that neural activity is necessary and sufficient to trigger alterations of vascular networks reveals an important feature of neurovascular interactions. (AU) | |
| Processo FAPESP: | 11/22639-8 - Estudo da relação estrutura-dinâmica em redes modulares |
| Beneficiário: | Cesar Henrique Comin |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |
| Processo FAPESP: | 11/50761-2 - Modelos e métodos de e-Science para ciências da vida e agrárias |
| Beneficiário: | Roberto Marcondes Cesar Junior |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |