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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Sensory-Related Neural Activity Regulates the Structure of Vascular Networks in the Cerebral Cortex

Texto completo
Autor(es):
Lacoste, Baptiste [1] ; Comin, Cesar H. [2] ; Ben-Zvi, Ayal [1] ; Kaeser, Pascal S. [1] ; Xu, Xiaoyin [3] ; Costa, Luciano da F. [2] ; Gu, Chenghua [1]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] Harvard Univ, Sch Med, Dept Neurobiol, Boston, MA 02115 - USA
[2] Univ Sao Paulo, IFSC, Sao Carlos, SP - Brazil
[3] Brigham & Womens Hosp, Dept Radiol, Boston, MA 02115 - USA
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: NEURON; v. 83, n. 5, p. 1117-1130, SEP 3 2014.
Citações Web of Science: 39
Resumo

Neurovascular interactions are essential for proper brain function. While the effect of neural activity on cerebral blood flow has been extensively studied, whether or not neural activity influences vascular patterning remains elusive. Here, we demonstrate that neural activity promotes the formation of vascular networks in the early postnatal mouse barrel cortex. Using a combination of genetics, imaging, and computational tools to allow simultaneous analysis of neuronal and vascular components, we found that vascular density and branching were decreased in the barrel cortex when sensory input was reduced by either a complete deafferentation, a genetic impairment of neurotransmitter release at thalamocortical synapses, or a selective reduction of sensory-related neural activity by whisker plucking. In contrast, enhancement of neural activity by whisker stimulation led to an increase in vascular density and branching. The finding that neural activity is necessary and sufficient to trigger alterations of vascular networks reveals an important feature of neurovascular interactions. (AU)

Processo FAPESP: 11/22639-8 - Estudo da relação estrutura-dinâmica em redes modulares
Beneficiário:Cesar Henrique Comin
Linha de fomento: Bolsas no Brasil - Doutorado
Processo FAPESP: 11/50761-2 - Modelos e métodos de e-Science para ciências da vida e agrárias
Beneficiário:Roberto Marcondes Cesar Junior
Linha de fomento: Auxílio à Pesquisa - Temático