| Texto completo | |
| Autor(es): |
Goncalves Frota, Karoline de Macedo
[1]
;
dos Santos, Raul Dias
[2]
;
Ribeiro, Valdenir Queiroz
[3]
;
Gomes Areas, Jose Alfredo
[4]
Número total de Autores: 4
|
| Afiliação do(s) autor(es): | [1] Univ Fed Piaui, Dept Nutr, BR-64049550 Teresina, PI - Brazil
[2] Univ Sao Paulo, Fac Med, Hosp Clin, Inst Coracao InCor, Sao Paulo, SP - Brazil
[3] Embrapa Meio Norte, Empresa Brasileira Pesquisa Agr, Teresina, PI - Brazil
[4] Univ Sao Paulo, Dept Nutr, Fac Saude Publ, Sao Paulo, SP - Brazil
Número total de Afiliações: 4
|
| Tipo de documento: | Artigo Científico |
| Fonte: | NUTRICION HOSPITALARIA; v. 31, n. 4, p. 1611-1619, APR 2015. |
| Citações Web of Science: | 10 |
| Resumo | |
Introduction: The risks of cardiovascular diseases, the leading cause of death in the world, can be reduced by diet. Cowpea protein has been shown to significantly reduce total cholesterol, LDL-cholesterol, and liver steatosis in hamsters. Objective: The objective of this proof-of-concept study was to verify whether the consumption of cowpea protein improves lipid profile and biomarkers of inflammation and endothelial dysfunction in adults with moderate hypercholesterolemia. Methods: In a randomized, double-blind, crossover design, 38 hypercholesterolemic subjects (LDL-cholesterol = 182.5 +/- 2.7 mg/dL) consumed 25 g/day of cowpea protein isolate or 25 g/day of casein (control group) for 6 weeks each, separated by a 4-week washout interval. Fasting blood samples were collected at baseline and at the end of each diet period. Lipids (total cholesterol, LDL-cholesterol, triglycerides, HDL-cholesterol) were determined by enzymatic methods, apolipoproteins (apoA-I and apoB) by standardized immunoassays, inflammatory biomarkers (C-reactive protein) by turbidimetry, and biomarkers of endothelial dysfunction (intercellular adhesion molecule 1 and vascular cell adhesion molecule 1) by enzyme-linked immunosorbent assays. Results and discussion: Consumption of cowpea protein significantly reduced total cholesterol (12 %), LDL-cholesterol (18.9 %), nonHDL-cholesterol (16 %) and apoB (14 %), and increased HDL-cholesterol (+2.7 %). No significant differences between treatment groups were observed for any of the serum inflammatory or endothelial dysfunction biomarkers. Conclusion: The present findings demonstrated the favorable effect of cowpea protein consumption on proatherogenic serum lipids and apoB in subjects with moderate hypercholesterolemia, similar to what was observed in a previous studies on animals. (AU) | |
| Processo FAPESP: | 12/15900-4 - Avaliação da biodisponibilidade de peptídeos de proteínas de tremoço, feijão caupi e amaranto por permeabilidade em células Caco-2 e alterações na expressão gênica de transportadores relacionados à absorção intestinal de colesterol |
| Beneficiário: | José Alfredo Gomes Arêas |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 07/05977-1 - Efeito da proteína isolada de feijão caupi (Vigna unguiculata L. Walp) nos marcadores de risco para doença cardiovascular em pacientes hipercolesterolêmicos |
| Beneficiário: | Karoline de Macedo Gonçalves Frota |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |