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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Laser therapy reduces gelatinolytic activity in the rat trigeminal ganglion during temporomandibular joint inflammation

Texto completo
Autor(es):
Desidera, A. C. [1] ; Nascimento, G. C. [2] ; Gerlach, R. F. [1] ; Leite-Panissi, C. R. A. [1, 2]
Número total de Autores: 4
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Dept Morphol Physiol & Basic Pathol, Dent Sch Ribeirao Preto, BR-14040904 Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Sci & Literature Ribeirao Preto, Sch Philosophy, Psychobiol Grad Program, BR-14040904 Ribeirao Preto, SP - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: ORAL DISEASES; v. 21, n. 5, p. 652-658, JUL 2015.
Citações Web of Science: 4
Resumo

ObjectivesTo investigate whether low-level laser therapy (LLLT) alters the expression and activity of MMP-2 and MMP-9 in the trigeminal ganglion (TG) during different stages of temporomandibular joint (TMJ) inflammation in rats. It also evaluated whether LLLT modifies mechanical allodynia and orofacial hyperalgesia. Materials and MethodsWistar rats (250g) were divided into groups that received saline (SAL) or complete Freund's adjuvant (CFA, 50l) in the TMJ, and that later underwent LLLT (20Jcm(-2)) at their TMJ or not (groups SAL, SAL+LLLT, CFA, and CFA+LLLT). LLLT was applied on days 3, 5, 7, and 9 after SAL or CFA. Mechanical allodynia was evaluated on days 1, 3, 5, 7, and 10; orofacial hyperalgesia was assessed on day 10. Gelatin zymography and in situ zymography aided quantification of MMPs in the TG. ResultsLow-level laser therapy abolished the reduction in the mechanical orofacial threshold and the increase in orofacial rubbing during the orofacial formalin test induced by CFA. LLLT also decreased the CFA-induced rise in the levels of MMP-9 and MMP-2 as well as the gelatinolytic activity in the TG. ConclusionLow-level laser therapy could constitute an adjuvant therapy to treat temporomandibular disorders and prevent inflammation-induced alterations in the levels of MMP-2 and MMP-9 and in the gelatinolytic activity in TGs. (AU)

Processo FAPESP: 11/07718-9 - Análise comportamental de ratos portadores de inflamação persistente da articulação temporomandibular: correlação com a quantificação de metaloproteinases em estruturas do sistema cerebral aversivo
Beneficiário:Glauce Crivelaro Do Nascimento
Modalidade de apoio: Bolsas no Brasil - Doutorado