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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Laser therapy reduces gelatinolytic activity in the rat trigeminal ganglion during temporomandibular joint inflammation

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Desidera, A. C. [1] ; Nascimento, G. C. [2] ; Gerlach, R. F. [1] ; Leite-Panissi, C. R. A. [1, 2]
Total Authors: 4
[1] Univ Sao Paulo, Dept Morphol Physiol & Basic Pathol, Dent Sch Ribeirao Preto, BR-14040904 Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Sci & Literature Ribeirao Preto, Sch Philosophy, Psychobiol Grad Program, BR-14040904 Ribeirao Preto, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: ORAL DISEASES; v. 21, n. 5, p. 652-658, JUL 2015.
Web of Science Citations: 4

ObjectivesTo investigate whether low-level laser therapy (LLLT) alters the expression and activity of MMP-2 and MMP-9 in the trigeminal ganglion (TG) during different stages of temporomandibular joint (TMJ) inflammation in rats. It also evaluated whether LLLT modifies mechanical allodynia and orofacial hyperalgesia. Materials and MethodsWistar rats (250g) were divided into groups that received saline (SAL) or complete Freund's adjuvant (CFA, 50l) in the TMJ, and that later underwent LLLT (20Jcm(-2)) at their TMJ or not (groups SAL, SAL+LLLT, CFA, and CFA+LLLT). LLLT was applied on days 3, 5, 7, and 9 after SAL or CFA. Mechanical allodynia was evaluated on days 1, 3, 5, 7, and 10; orofacial hyperalgesia was assessed on day 10. Gelatin zymography and in situ zymography aided quantification of MMPs in the TG. ResultsLow-level laser therapy abolished the reduction in the mechanical orofacial threshold and the increase in orofacial rubbing during the orofacial formalin test induced by CFA. LLLT also decreased the CFA-induced rise in the levels of MMP-9 and MMP-2 as well as the gelatinolytic activity in the TG. ConclusionLow-level laser therapy could constitute an adjuvant therapy to treat temporomandibular disorders and prevent inflammation-induced alterations in the levels of MMP-2 and MMP-9 and in the gelatinolytic activity in TGs. (AU)

FAPESP's process: 11/07718-9 - Behavioral analysis of rats with persistent inflammation of the temporomandibular joint: correlation with the quantification of metalloproteinases in the structures of the brain aversive system
Grantee:Glauce Crivelaro Do Nascimento
Support type: Scholarships in Brazil - Doctorate