Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Characterization of the antioxidant activity of aglycone and glycosylated derivatives of hesperetin: an in vitro and in vivo study

Texto completo
Autor(es):
de Souza, Veronica Tricoli [1] ; Dini de Franco, Elida Paula [1] ; Melo Branco de Araujo, Maria Elisa [1] ; Fernandes Messias, Marcia Cristina [1] ; Marinho Priviero, Fernanda Bruschi [1] ; Frankland Sawaya, Alexandra C. H. [2] ; Carvalho, Patricia de Oliveira [1]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] Univ San Francisco, Multidisciplinary Res Lab, Sao Francisco De Assis Ave 218, BR-12916900 Braganca Paulista, SP - Brazil
[2] State Univ Campinas UNICAMP, Inst Biol, Dept Plant Biol, BR-13083970 Campinas, SP - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: JOURNAL OF MOLECULAR RECOGNITION; v. 29, n. 2, p. 80-87, FEB 2016.
Citações Web of Science: 15
Resumo

The flavonoids are mainly present in Citrus fruits as their glycosyl derivatives. This study was conducted comparing in vitro xanthine oxidase inhibitory activity of the aglycone hesperetin and its glycosylated forms (hesperidin and G-hesperidin) and their effects on the plasma lipid profile and the oxidative-antioxidative system (TBARS and antioxidant enzymes) in rats. The concentrations of the major conjugated metabolites in rat plasma after oral administration of these compounds were also determined. Wistar male rats were randomly assigned to three groups (n = 6) supplemented for 30 days with 1 mmol/kg body mass of hesperetin, hesperidin or G-hesperidin. Hesperetin was a stronger xanthine oxidase inhibitor (IC50=53 mu M and K-i = 17.3 mu M) than the glycosylate derivatives. Supplementation with the three compounds led to a lower (more favorable) atherogenic index, and an antioxidant preventive effect from the increase of hepatic superoxide dismutase was observed associated to HT supplementation, possibly because of the higher level of hesperetin-glucuronide in rat plasma. Copyright (C) 2015 John Wiley \& Sons, Ltd. (AU)

Processo FAPESP: 12/11050-6 - Efeitos no metabolismo lipídico e na composição de ácidos graxos plasmáticos e teciduais de animais tratados com hesperidina antes e após hidrólise enzimática
Beneficiário:Verônica Trícoli de Souza
Modalidade de apoio: Bolsas no Brasil - Mestrado
Processo FAPESP: 12/20393-4 - Avaliação em ratos do perfil lipidômico e biodisponibilidade de flavonóides naturais e biotransformados
Beneficiário:Patrícia de Oliveira Carvalho
Modalidade de apoio: Auxílio à Pesquisa - Regular