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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Characterization of the antioxidant activity of aglycone and glycosylated derivatives of hesperetin: an in vitro and in vivo study

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Author(s):
de Souza, Veronica Tricoli [1] ; Dini de Franco, Elida Paula [1] ; Melo Branco de Araujo, Maria Elisa [1] ; Fernandes Messias, Marcia Cristina [1] ; Marinho Priviero, Fernanda Bruschi [1] ; Frankland Sawaya, Alexandra C. H. [2] ; Carvalho, Patricia de Oliveira [1]
Total Authors: 7
Affiliation:
[1] Univ San Francisco, Multidisciplinary Res Lab, Sao Francisco De Assis Ave 218, BR-12916900 Braganca Paulista, SP - Brazil
[2] State Univ Campinas UNICAMP, Inst Biol, Dept Plant Biol, BR-13083970 Campinas, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: JOURNAL OF MOLECULAR RECOGNITION; v. 29, n. 2, p. 80-87, FEB 2016.
Web of Science Citations: 15
Abstract

The flavonoids are mainly present in Citrus fruits as their glycosyl derivatives. This study was conducted comparing in vitro xanthine oxidase inhibitory activity of the aglycone hesperetin and its glycosylated forms (hesperidin and G-hesperidin) and their effects on the plasma lipid profile and the oxidative-antioxidative system (TBARS and antioxidant enzymes) in rats. The concentrations of the major conjugated metabolites in rat plasma after oral administration of these compounds were also determined. Wistar male rats were randomly assigned to three groups (n = 6) supplemented for 30 days with 1 mmol/kg body mass of hesperetin, hesperidin or G-hesperidin. Hesperetin was a stronger xanthine oxidase inhibitor (IC50=53 mu M and K-i = 17.3 mu M) than the glycosylate derivatives. Supplementation with the three compounds led to a lower (more favorable) atherogenic index, and an antioxidant preventive effect from the increase of hepatic superoxide dismutase was observed associated to HT supplementation, possibly because of the higher level of hesperetin-glucuronide in rat plasma. Copyright (C) 2015 John Wiley \& Sons, Ltd. (AU)

FAPESP's process: 12/11050-6 - Effects on lipid metabolism and plasmatic and tissue fatty acid composition in animals treated with HESPEREDIN before and after enzymatic hydrolysis
Grantee:Verônica Trícoli de Souza
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 12/20393-4 - Analysis of the lipodemic profile and bioavailability of natural and bio-transformed flavonoids in rats
Grantee:Patrícia de Oliveira Carvalho
Support Opportunities: Regular Research Grants