Anti-Mycobacterium tuberculosis and Cytotoxicity Activities of Ruthenium(II)/Bipyridine/Diphosphine/Pyrimidine-2-thiolate Complexes: The Role of the Non-Coordinated N-Atom

Autor(es)

Lima, Benedicto A. V. ^[1] ; Correa, Rodrigo S. ^{[2, 1]} ; Graminha, Angelica E. ^[1] ; Kuznetsov, Aleksey ^[1] ; Ellena, Javier ^[3] ; Pavan, Fernando R. ^[4] ; Leite, Clarice Q. F. ^[4] ; Batista, Alzir A. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Carlos, Dept Quim, CP 676, BR-13565905 Sao Carlos, SP - Brazil

^[2] Univ Fed Ouro Preto, ICEB, Dept Quim, BR-35400000 Ouro Preto, MG - Brazil

^[3] Univ Sao Paulo, Inst Fis Sao Carlos, CP 780, BR-13560970 Sao Carlos, SP - Brazil

^[4] Univ Estadual Paulista Unesp, Fac Ciencias Farmaceut, Dept Ciencias Biol, BR-14800900 Araraquara, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Journal of the Brazilian Chemical Society; v. 27, n. 1, p. 30-40, JAN 2016.
• Citações Web of Science: 11

Resumo

The {[}Ru(Spym)(bipy)(P-P)] PF6, {[}Spym = pyrimidine-2-thiolate anion; P-P = 1,2-bis(diphenylphosphino) ethane, 1,3-bis(diphenylphosphino) propane and 1,1'-bis(diphenylphosphino) ferrocene] complexes were synthesized and characterized by spectroscopic, electrochemical and elemental analysis, and by X-ray crystallography. The minimal inhibitory concentration (MIC) of the compounds against Mycobacterium tuberculosis and the complex concentration causing 50% tumor cell growth inhibition (IC50) against breast cancer cells, MDA-MB-231, were determined. All three compounds gave promising values in both tests. It is interesting to mention that all three complexes display MICs against Mycobacterium tuberculosis showing higher activity than cycloserine, a second line drug used in the treatment of the illness. The complexes interact weakly with the DNA. (AU)

• Processo FAPESP: 12/06013-4 - Estudo da expressão de genes de apoptose, ciclo celular, reparo do DNA e estresse oxidativo em células de carcinoma de pulmão humano tratadas com complexos de fórmula geral [Ru(AA)(dppb)(bipy)]PF6
• Beneficiário: Alzir Azevedo Batista
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 13/26559-4 - Modificações estruturais em complexos de Ru(II) biologicamente ativos para o desenho de novos candidatos a metalofármacos
• Beneficiário: Rodrigo de Souza Corrêa
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado