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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Anti-Mycobacterium tuberculosis and Cytotoxicity Activities of Ruthenium(II)/Bipyridine/Diphosphine/Pyrimidine-2-thiolate Complexes: The Role of the Non-Coordinated N-Atom

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Author(s):
Lima, Benedicto A. V. [1] ; Correa, Rodrigo S. [2, 1] ; Graminha, Angelica E. [1] ; Kuznetsov, Aleksey [1] ; Ellena, Javier [3] ; Pavan, Fernando R. [4] ; Leite, Clarice Q. F. [4] ; Batista, Alzir A. [1]
Total Authors: 8
Affiliation:
[1] Univ Fed Sao Carlos, Dept Quim, CP 676, BR-13565905 Sao Carlos, SP - Brazil
[2] Univ Fed Ouro Preto, ICEB, Dept Quim, BR-35400000 Ouro Preto, MG - Brazil
[3] Univ Sao Paulo, Inst Fis Sao Carlos, CP 780, BR-13560970 Sao Carlos, SP - Brazil
[4] Univ Estadual Paulista Unesp, Fac Ciencias Farmaceut, Dept Ciencias Biol, BR-14800900 Araraquara, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: Journal of the Brazilian Chemical Society; v. 27, n. 1, p. 30-40, JAN 2016.
Web of Science Citations: 11
Abstract

The {[}Ru(Spym)(bipy)(P-P)] PF6, {[}Spym = pyrimidine-2-thiolate anion; P-P = 1,2-bis(diphenylphosphino) ethane, 1,3-bis(diphenylphosphino) propane and 1,1'-bis(diphenylphosphino) ferrocene] complexes were synthesized and characterized by spectroscopic, electrochemical and elemental analysis, and by X-ray crystallography. The minimal inhibitory concentration (MIC) of the compounds against Mycobacterium tuberculosis and the complex concentration causing 50% tumor cell growth inhibition (IC50) against breast cancer cells, MDA-MB-231, were determined. All three compounds gave promising values in both tests. It is interesting to mention that all three complexes display MICs against Mycobacterium tuberculosis showing higher activity than cycloserine, a second line drug used in the treatment of the illness. The complexes interact weakly with the DNA. (AU)

FAPESP's process: 12/06013-4 - Study of apoptosis gene expression, celular cyclic, DNA repair and oxidative stress in cells of human lang carcinoma treated with complexes with general formula [Ru(AA)(dppb)(bipy)]PF6
Grantee:Alzir Azevedo Batista
Support Opportunities: Regular Research Grants
FAPESP's process: 13/26559-4 - Structural modifications in biologically active Ru(II) complexes toward the design of new metallodrug candidates
Grantee:Rodrigo de Souza Corrêa
Support Opportunities: Scholarships in Brazil - Post-Doctoral