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Texto completo
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| Autor(es): |
Dantonio, Valter
[1, 2]
;
Batalhao, Marcelo E.
[3]
;
Fernandes, Marcia H. M. R.
[4]
;
Komegae, Evilin N.
[5]
;
Buqui, Gabriela A.
[6]
;
Lopes, Norberto P.
[6]
;
Gargaglioni, Luciane H.
[1, 2]
;
Carnio, Evelin C.
[3]
;
Steiner, Alexandre A.
[5]
;
Bicego, Kenia C.
[1, 2]
Número total de Autores: 10
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| Afiliação do(s) autor(es): | [1] Sao Paulo State Univ, Dept Anim Morphol & Physiol, Coll Agr & Vet Sci, Sao Paulo - Brazil
[2] Natl Inst Sci & Technol Comparat Physiol INCT Fis, Sao Paulo - Brazil
[3] Univ Sao Paulo, Nursing Sch Ribeirao Preto, Sao Paulo - Brazil
[4] Sao Paulo State Univ, Dept Anim Sci, Coll Agr & Vet Sci, Sao Paulo - Brazil
[5] Univ Sao Paulo, Inst Biomed Sci, Dept Immunol, Sao Paulo, SP - Brazil
[6] Univ Sao Paulo, Fac Pharmaceut Sci Ribeirao Preto, Dept Chem & Phys, Nucleo Pesquisa Prod Nat & Sintet, Sao Paulo - Brazil
Número total de Afiliações: 6
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| Tipo de documento: |
Artigo Científico
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| Fonte: |
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY;
v. 310,
n. 10,
p. R896-R905,
MAY 15 2016.
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| Citações Web of Science: |
3
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| Resumo |
Nitric oxide (NO) plays a role in thermogenesis but does not mediate immune-to-brain febrigenic signaling in rats. There are suggestions of a different situation in birds, but the underlying evidence is not compelling. The present study was designed to clarify this matter in 5-day-old chicks challenged with a low or high dose of bacterial LPS. The lower LPS dose (2 mu g/kg im) induced fever at 3-5 h postinjection, whereas 100 mu g/kg im decreased core body temperature (T-c) (at 1 h) followed by fever (at 4 or 5 h). Plasma nitrate levels increased 4 h after LPS injection, but they were not correlated with the magnitude of fever. The NO synthase inhibitor (NG-nitro-L-arginine methyl ester, L-NAME; 50 mg/kg im) attenuated the fever induced by either dose of LPS and enhanced the magnitude of the Tc reduction induced by the high dose in chicks at 31-32 degrees C. These effects were associated with suppression of metabolic rate, at least in the case of the high LPS dose. Conversely, the effects of L-NAME on Tc disappeared in chicks maintained at 35-36 degrees C, suggesting that febrigenic signaling was essentially unaffected. Accordingly, the LPS-induced rise in the brain level of PGE(2) was not affected by L-NAME. Moreover, L-NAME augmented LPS-induced huddling, which is indicative of compensatory mechanisms to run fever in the face of attenuated thermogenesis. Therefore, as in rats, systemic inhibition of NO synthesis attenuates LPS-induced fever in chicks by affecting thermoeffector activity and not by interfering with immune-to-brain signaling. This may constitute a conserved effect of NO in endotherms. (AU) |
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| Processo FAPESP: |
13/13386-4 - Óxido nítrico e grelina como possíveis mediadores/moduladores da resposta febril em pintainhos de frangos de corte
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| Beneficiário: | Kênia Cardoso Bícego |
| Linha de fomento: |
Auxílio à Pesquisa - Regular
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| Processo FAPESP: |
12/03831-8 - Elo entre balanço energético e inflamação sistêmica: papel da leptina
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| Beneficiário: | Alexandre Alarcon Steiner |
| Linha de fomento: |
Auxílio à Pesquisa - Apoio a Jovens Pesquisadores
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| Processo FAPESP: |
14/50265-3 - Metabolismo e distribuição de xenobióticos naturais e sintéticos: da compreensão dos processos reacionais à geração de imagens teciduais
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| Beneficiário: | Norberto Peporine Lopes |
| Linha de fomento: |
Auxílio à Pesquisa - Programa BIOTA - Temático
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| Processo FAPESP: |
12/19966-0 - Padrão cardiorrespiratório e ciclo sono-vigília de ratos e ratas expostos à fluoxetina durante o período prenatal
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| Beneficiário: | Luciane Helena Gargaglioni Batalhão |
| Linha de fomento: |
Auxílio à Pesquisa - Regular
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| Processo FAPESP: |
14/13586-6 - Efeito da grelina sobre o eixo GH/IGF-1 em ratos submetidos à endotoxemia
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| Beneficiário: | Evelin Capellari Cárnio |
| Linha de fomento: |
Auxílio à Pesquisa - Regular
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