Aerobic Exercise Modulates the Free Fatty Acids and Inflammatory Response During Obesity and Cancer Cachexia

Autor(es)

Teixeira, Alexandre Abilio de S. ; Lira, Fabio S. ; Pimentel, Gustavo D. ; de Souza, Camila Oliveira ; Batatinha, Helena ; Biondo, Luana A. ; Yamashita, Alex S. ; Lima Junior, Edson A. ; Rosa Neto, Jose C.

• Tipo de documento: Artigo Científico
• Fonte: CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION; v. 26, n. 3, p. 187-198, 2016.
• Citações Web of Science: 8

Resumo

White adipose tissue (WAT) is no longer considered a tissue whose main function is the storage of TAG. Since the discovery of leptin in 1994, several studies have elucidated the important role of WAT as an endocrine organ, the source of the adipokines. The low-grade inflammation observed in obese and cancer cachexia patients is explained, at least partially, by the exacerbated release of proinflammatory adipokines. Despite of the recent progress in the characterization of the various adipokines and lipokines produced by WAT, little is known about the mechanisms regulating the secretion of these molecules in different physiological and pathological circumstances. Chronic exercise is a nonpharmacological therapy employed in several chronic diseases and shows an anti-inflammatory effect through the regulation of the cytokine network. In this review, we address the potential mechanisms by which the aerobic physical exercise modulate the production and release of inflammatory adipokines, as well as the inflammation-lipolysis axis in WAT, with special focus in the therapeutic role of exercise in obesity-associated insulin resistance and cancer cachexia. (AU)

• Processo FAPESP: 13/09367-4 - Efeitos metabólicos da doxorrubicina no músculo esquelético e tecido adiposo: possível papel adjuvante do treinamento físico e metformina
• Beneficiário: José Cesar Rosa Neto
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 13/25310-2 - Avaliação da resposta imuno-metabólica em células sanguíneas em indivíduos obesos: papel do exercício físico e do PPAR-gama
• Beneficiário: Fábio Santos de Lira
• Modalidade de apoio: Auxílio à Pesquisa - Regular