Advanced search
Start date
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Aerobic Exercise Modulates the Free Fatty Acids and Inflammatory Response During Obesity and Cancer Cachexia

Full text
Teixeira, Alexandre Abilio de S. ; Lira, Fabio S. ; Pimentel, Gustavo D. ; de Souza, Camila Oliveira ; Batatinha, Helena ; Biondo, Luana A. ; Yamashita, Alex S. ; Lima Junior, Edson A. ; Rosa Neto, Jose C.
Total Authors: 9
Document type: Journal article
Source: CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION; v. 26, n. 3, p. 187-198, 2016.
Web of Science Citations: 8

White adipose tissue (WAT) is no longer considered a tissue whose main function is the storage of TAG. Since the discovery of leptin in 1994, several studies have elucidated the important role of WAT as an endocrine organ, the source of the adipokines. The low-grade inflammation observed in obese and cancer cachexia patients is explained, at least partially, by the exacerbated release of proinflammatory adipokines. Despite of the recent progress in the characterization of the various adipokines and lipokines produced by WAT, little is known about the mechanisms regulating the secretion of these molecules in different physiological and pathological circumstances. Chronic exercise is a nonpharmacological therapy employed in several chronic diseases and shows an anti-inflammatory effect through the regulation of the cytokine network. In this review, we address the potential mechanisms by which the aerobic physical exercise modulate the production and release of inflammatory adipokines, as well as the inflammation-lipolysis axis in WAT, with special focus in the therapeutic role of exercise in obesity-associated insulin resistance and cancer cachexia. (AU)

FAPESP's process: 13/09367-4 - Metabolic effects of doxorubicin on the muscle and adipose tissue: do exercise and metformin reduce the damage?
Grantee:José Cesar Rosa Neto
Support type: Regular Research Grants
FAPESP's process: 13/25310-2 - Evaluation of immune-metabolic blood cells in obese subjects: role of physical exercise and PPAR-gamma
Grantee:Fábio Santos de Lira
Support type: Regular Research Grants