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Evaluation of immune-metabolic blood cells in obese subjects: role of physical exercise and PPAR-gamma

Abstract

Previous studies have shown that sedentary lifestyle is associated with the development of dyslipidemia, chronic low-grade inflammation and obesity. Based on existing literature, and in previous studies of our group, we hypothesized that changes immuno - metabolic, systemic and tissue, favoring the onset and progression of several diseases and are directly involved with the state of physical training. Additionally, we suggest the involvement of gene transcription factors coordinating these changes, such as the activated receptor peroxisome proliferator-gamma (PPAR - ³). Given these facts the objective of this project is to examine the immune response of individuals in different metabolic conditions of physical training, attempt to clarify the response of the project participants to different exercise programs. To test our hypothesis , initially, will be recruited 45 subjects, men aged 18-30 years were obese (BMI e 30 kg/m2). The group will consist of three subdivisions, to be: 1) Sedentary ( not engage in any physical training), 2) moderate exercise training (aerobic training held at 50 % of maximal aerobic power for 30 minutes), 3) Training high intensity physical (aerobic training held at 100 % of maximal aerobic power, intermittently, 1 minute exercise for 1 minute of rest). Physical training of both groups will be conducted in cycle ergometer 3 times per week for 16 weeks. Blood samples will be performed at rest and immediately after acute bout of exercise 5 times, 1) Pre-training, 2) after 4 weeks of training, 3) after 8 weeks of training, 4) after 12 weeks of training, 5) after 16 weeks of training. Evaluate the metabolic profile, inflammation, as well as the phenotype (pro-or anti-inflammatory) of blood cells and gene expression and activation of the transcription factor PPAR-³ gene . Experiments with monocyte culture (in vitro) and animal models (noucates PPAR-³) will provide better understanding of the involvement of PPAR-³ in regulating immune-metabolic. This project aims to find a better understanding of mechanisms of action of physical, checking the direct impact on the elucidation of the issues related to dyslipidemia, as well as the development of new therapies that target intracellular pathways underlying the inflammatory process. (AU)

Scientific publications (25)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SILVEIRA, LOREANA SANCHES; BIONDO, LUANA AMORIM; DE SOUZA TEIXEIRA, ALEXANDRE ABILIO; DE LIMA JUNIOR, EDSON ALVES; CASTOLDI, ANGELA; SARAIVA CAMARA, NIELS OLSEN; FESTUCCIA, WILLIAN T.; ROSA-NETO, JOSE CESAR; LIRA, FABIO SANTOS. Macrophage immunophenotype but not anti-inflammatory profile is modulated by peroxisome proliferator-activated receptor gamma (PPAR gamma) in exercised obese mice. EXERCISE IMMUNOLOGY REVIEW, v. 26, p. 94-106, 2020. Web of Science Citations: 0.
FIGUEIREDO, CAIQUE; ANTUNES, BARBARA M.; GIACON, THAIS R.; VANDERLEI, LUIZ C. M.; CAMPOS, EDUARDO Z.; PERES, FERNANDO P.; CLARK, NICOLAS W.; PANISSA, VALERIA L. G.; LIRA, FABIO S. Influence of Acute and Chronic High-Intensity Intermittent Aerobic Plus Strength Exercise on BDNF, Lipid and Autonomic Parameters. JOURNAL OF SPORTS SCIENCE AND MEDICINE, v. 18, n. 2, p. 359-368, JUN 2019. Web of Science Citations: 0.
SILVEIRA, LOREANA SANCHES; PEREIRA BATATINHA, HELENA ANGELICA; CASTOLDI, ANGELA; SARAIVA CAMARA, NIELS OLSEN; FESTUCCIA, WILLIAN T.; SOUZA, CAMILA OLIVEIRA; ROSA NETO, JOSE CESAR; LIRA, FABIO SANTOS. Exercise rescues the immune response fine-tuned impaired by peroxisome proliferator-activated receptors deletion in macrophages. Journal of Cellular Physiology, v. 234, n. 4, p. 5241-5251, APR 2019. Web of Science Citations: 1.
PANISSA, VALERIA L. G.; FUKUDA, DAVID H.; DE OLIVEIRA, FLAVIANE P.; PARMEZZANI, SERGIO S.; CAMPOS, EDUARDO Z.; ROSSI, FABRICIO E.; FRANCHINI, EMERSON; LIRA, FABIO S. Maximum Strength Development and Volume-Load during Concurrent High Intensity Intermittent Training Plus Strength or Strength-Only Training. JOURNAL OF SPORTS SCIENCE AND MEDICINE, v. 17, n. 4, p. 623-632, DEC 2018. Web of Science Citations: 0.
INOUE, DANIELA S.; PANISSA, VALERIA L.; ANTUNES, BARBARA M.; OLIVEIRA, FLAVIANE P.; MALTA, RAONI B.; CALDEIRA, RENAN S.; CAMPOS, EDUARDO Z.; PIMENTEL, GUSTAVO D.; FRANCHINI, EMERSON; LIRA, FABIO S. Reduced leptin level is independent of fat mass changes and hunger scores from high-intensity intermittent plus strength training. JOURNAL OF SPORTS MEDICINE AND PHYSICAL FITNESS, v. 58, n. 7-8, p. 1045-1051, JUL-AUG 2018. Web of Science Citations: 3.
SILVEIRA, LOREANA S.; PIMENTEL, GUSTAVO D.; SOUZA, CAMILA O.; BIONDO, LUANA A.; TEIXEIRA, ALEXANDRE ABILIO S.; LIMA, EDSON A.; BATATINHA, HELENA A. P.; ROSA NETO, JOSE C.; LIRA, FABIO S. Effect of an acute moderate-exercise session on metabolic and inflammatory profile of PPAR- knockout mice. Cell Biochemistry and Function, v. 35, n. 8, p. 510-517, DEC 2017. Web of Science Citations: 4.
ROSSI, FABRICIO EDUARDO; LECCA, ANDERSON ROGERIO; PERON MARTINS, LUIZ GUSTAVO; OTA TAKAHASHI, LUCIANA SANAE; DESTRO CHRISTOFARO, DIEGO GIULIANO; GOBBO, LUIS ALBERTO; FREITAS JR, ISMAEL F. Physical exercise programs at Basic Healthcare Units decrease body fat and improve the functional capacity of women over 50 years old. JOURNAL OF EXERCISE REHABILITATION, v. 13, n. 3, p. 315-321, JUN 2017. Web of Science Citations: 2.
BATATINHA, HELENA A. P.; LIMA, EDSON A.; TEIXEIRA, ALEXANDRE A. S.; SOUZA, CAMILA O.; BIONDO, LUANA A.; SILVEIRA, LOREANA S.; LIRA, FABIO S.; ROSA NETO, JOSE C. Association Between Aerobic Exercise and Rosiglitazone Avoided the NAFLD and Liver Inflammation Exacerbated in PPAR-alpha Knockout Mice. Journal of Cellular Physiology, v. 232, n. 5, p. 1008-1019, MAY 2017. Web of Science Citations: 9.
ROSSI, FABRICIO EDUARDO; GONCALVES PANISSA, VALERIA LEME; MONTEIRO, PAULA AULVES; GEROSA-NETO, JOSE; CAPERUTO, ERICO CHAGAS; CHOLEWA, JASON MICHAEL; ZAGATTO, ALESSANDRO MOURA; LIRA, FABIO SANTOS. Caffeine supplementation affects the immunometabolic response to concurrent training. JOURNAL OF EXERCISE REHABILITATION, v. 13, n. 2, p. 179-184, APR 2017. Web of Science Citations: 6.
MONTEIRO, PAULA ALVES; CAMPOS, EDUARDO ZAPATERRA; DE OLIVEIRA, FLAVIANE POLETO; PERES, FERNANDO PIERIN; ROSA-NETO, JOSE CESAR; PIMENTEL, GUSTAVO DUARTE; LIRA, FABIO SANTOS. Modulation of inflammatory response arising from high-intensity intermittent and concurrent strength training in physically active males. CYTOKINE, v. 91, p. 104-109, MAR 2017. Web of Science Citations: 5.
CABRAL-SANTOS, CAROLINA; GEROSA-NETO, JOSE; INOUE, DANIELA S.; ROSSI, FABRICIO E.; CHOLEWA, JASON M.; CAMPOS, EDUARDO Z.; PANISSA, VALERIA L. G.; LIRA, FABIO S. Physiological Acute Response to High-Intensity Intermittent and Moderate-Intensity Continuous 5 km Running Performance: Implications for Training Prescription. Journal of Human Kinetics, v. 56, n. 1, p. 127-137, FEB 2017. Web of Science Citations: 3.
GEROSA-NETO, JOSE; ANTUNES, BARBARA M. M.; CAMPOS, EDUARDO Z.; RODRIGUES, JHENNYFER; FERRARI, GUSTAVO D.; NETO, JOSE C. ROSA; BUENO JUNIOR, CARLOS R.; LIRA, FABIO S. Impact of long-term high-intensity interval and moderate-intensity continuous training on subclinical inflammation in overweight/obese adults. JOURNAL OF EXERCISE REHABILITATION, v. 12, n. 6, p. 575-580, DEC 2016. Web of Science Citations: 9.
SANTOS, CAROLINA C.; DINIZ, TIEGO A.; INOUE, DANIELA S.; GEROSA-NETO, JOSE; PANISSA, VALERIA L. G.; PIMENTEL, GUSTAVO DUARTE; CAMPOS, EDUARDO Z.; HOFMANN, PETER; LIRA, FABIO S. Influence to high-intensity intermittent and moderate-intensity continuous exercise on indices of cardio-inflammatory health in men. JOURNAL OF EXERCISE REHABILITATION, v. 12, n. 6, p. 618-623, DEC 2016. Web of Science Citations: 1.
CABRAL-SANTOS, CAROLINA; CASTRILLON, CARLOS I. M.; MIRANDA, RODOLFO A. T.; MONTEIRO, PAULA A.; INOUE, DANIELA S.; CAMPOS, EDUARDO Z.; HOFMANN, PETER; LIRA, FABIO S. Inflammatory Cytokines and BDNF Response to High-Intensity Intermittent Exercise: Effect the Exercise Volume. FRONTIERS IN PHYSIOLOGY, v. 7, NOV 4 2016. Web of Science Citations: 14.
AGOSTINETE, RICARDO R.; ROSSI, FABRICIO E.; MAGALHAES, ALAN JOSE B.; ROCHA, ANA PAULA R.; PARMEZZANI, SERGIO S.; GEROSA-NETO, JOSE; CHOLEWA, JASON M.; LIRA, FABIO S. Immunometabolic Responses after Short and Moderate Rest Intervals to Strength Exercise with and without Similar Total Volume. FRONTIERS IN PHYSIOLOGY, v. 7, OCT 25 2016. Web of Science Citations: 1.
GONCALVES PANISSA, VALERIA LEME; JULIO, URSULA FERREIRA; DINIZ, TIEGO APARECIDO; MELLO ANTUNES, BARBARA DE MOURA; LIRA, FABIO SANTOS; TAKITO, MONICA YURI; FRANCHINI, EMERSON. Postprandial lipoprotein profile in two modes of high-intensity intermittent exercise. JOURNAL OF EXERCISE REHABILITATION, v. 12, n. 5, p. 476-482, OCT 2016. Web of Science Citations: 3.
INOUE, DANIELA S.; PANISSA, VALERIA L. G.; MONTEIRO, PAULA A.; GEROSA-NETO, JOSE; ROSSI, FABRICIO E.; ANTUNES, BARBARA M. M.; FRANCHINI, EMERSON; CHOLEWA, JASON M.; GOBBO, LUIS A.; LIRA, FABIO S. IMMUNOMETABOLIC RESPONSES TO CONCURRENT TRAINING: THE EFFECTS OF EXERCISE ORDER IN RECREATIONAL WEIGHTLIFTERS. JOURNAL OF STRENGTH AND CONDITIONING RESEARCH, v. 30, n. 7, p. 1960-1967, JUL 2016. Web of Science Citations: 6.
CABRAL-SANTOS, C.; GIACON, T. R.; CAMPOS, E. Z.; GEROSA-NETO, J.; RODRIGUES, B.; VANDERLEI, L. C. M.; LIRA, F. S. Impact of High-intensity Intermittent and Moderate-intensity Continuous Exercise on Autonomic Modulation in Young Men. INTERNATIONAL JOURNAL OF SPORTS MEDICINE, v. 37, n. 6, p. 431-435, JUN 2016. Web of Science Citations: 5.
GEROSA-NETO, JOSE; ROSSI, FABRICIO E.; CAMPOS, EDUARDO Z.; ANTUNES, BARBARA M. M.; CHOLEWA, JASON M.; LIRA, FABIO S. IMPACT OF SHORT AND MODERATE REST INTERVALS ON THE ACUTE IMMUNOMETABOLIC RESPONSE TO EXHAUSTIVE STRENGTH EXERCISE: PART II. JOURNAL OF STRENGTH AND CONDITIONING RESEARCH, v. 30, n. 6, p. 1570-1576, JUN 2016. Web of Science Citations: 3.
PANISSA, VALERIA L. G.; JULIO, URSULA F.; FRANCA, VANESSA; LIRA, FABIO S.; HOFMANN, PETER; TAKITO, MONICA Y.; FRANCHINI, EMERSON. Sex-Related Differences in Self-Paced All Out High-Intensity Intermittent Cycling: Mechanical and Physiological Responses. JOURNAL OF SPORTS SCIENCE AND MEDICINE, v. 15, n. 2, p. 372-378, JUN 2016. Web of Science Citations: 5.
SANCHES SILVEIRA, LOREANA; MELLO ANTUNES, BARBARA DE MOURA; ARAUJO MINARI, ANDRE LUIS; THOMATIELI DOS SANTOS, RONALDO VAGNER; ROSA NETO, JOSE CESAR; LIRA, FABIO SANTOS. Macrophage Polarization: Implications on Metabolic Diseases and the Role of Exercise. CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION, v. 26, n. 2, p. 115-132, 2016. Web of Science Citations: 4.
TEIXEIRA, ALEXANDRE ABILIO DE S.; LIRA, FABIO S.; PIMENTEL, GUSTAVO D.; DE SOUZA, CAMILA OLIVEIRA; BATATINHA, HELENA; BIONDO, LUANA A.; YAMASHITA, ALEX S.; LIMA JUNIOR, EDSON A.; ROSA NETO, JOSE C. Aerobic Exercise Modulates the Free Fatty Acids and Inflammatory Response During Obesity and Cancer Cachexia. CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION, v. 26, n. 3, p. 187-198, 2016. Web of Science Citations: 8.
CABRAL-SANTOS, CAROLINA; GEROSA-NETO, JOSE; INOUE, DANIELA SAYURI; GONALVES PANISSA, VALERIA LEME; GOBBO, LUIS ALBERTO; ZAGATTO, ALESSANDRO MOURA; CAMPOS, EDUARDO ZAPATERRA; LIRA, FABIO SANTOS. Similar Anti-Inflammatory Acute Responses from Moderate-Intensity Continuous and High-Intensity Intermittent Exercise. JOURNAL OF SPORTS SCIENCE AND MEDICINE, v. 14, n. 4, p. 849-856, DEC 2015. Web of Science Citations: 18.
MONTEIRO, PAULA ALVES; CHEN, KONG Y.; LIRA, FABIO SANTOS; CICOTTI SARAIVA, BRUNA THAMYRES; MELLO ANTUNES, BARBARA MOURA; CAMPOS, EDUARDO ZAPATERRA; FREITAS, JR., ISMAEL FORTE. Concurrent and aerobic exercise training promote similar benefits in body composition and metabolic profiles in obese adolescents. LIPIDS IN HEALTH AND DISEASE, v. 14, NOV 26 2015. Web of Science Citations: 12.
LIRA, FABIO S.; PANISSA, VALERIA L. G.; JULIO, URSULA F.; FRANCHINI, EMERSON. Differences in metabolic and inflammatory responses in lower and upper body high-intensity intermittent exercise. EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY, v. 115, n. 7, p. 1467-1474, JUL 2015. Web of Science Citations: 15.

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