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Cachexia associated with cancer and lipid metabolism: can chronic exercise affect fatty acids location and profile in muscle?

Grant number: 16/13810-9
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): September 01, 2016
Effective date (End): December 31, 2017
Field of knowledge:Biological Sciences - Biochemistry - Metabolism and Bioenergetics
Principal researcher:Marilia Cerqueira Leite Seelaender
Grantee:Gabriela Salim Ferreira de Castro
Home Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:12/50079-0 - Systemic inflammation in cachectic cancer patients: mechanisms and therapeutical strategies, a translational medicine approach, AP.TEM

Abstract

Cachexia is a wasting syndrome defined by a continuous loss of skeletal muscle mass due to an imbalance between protein synthesis and degradation with or without body fat loss. Weight loss is the most prominent characteristic of cachexia and is strongly associated with mortality. Inflammation has a central role in CC and affects several organs, including adipose tissue in which CC increases lipolysis and secretion of inflammatory cytokines. Muscle is one of the most affected organs. CC generate an increase in muscle proteolysis and secretion of amino acids, a decrease in protein synthesis and development of insulin resistance. Intramuscular triacylglycerol represents an important energy source during prolonged exercise and exercise also increases muscle fatty acid uptake. Although fatty acid metabolism is extensively studied in tumours and adipose tissue, little is known about muscle fatty acid metabolism.The overall objective is to characterize the fatty acid profile and TAG content of muscle and perimysial adipocytes and to identify whether chronic endurance exercise alter muscle lipid profile and localization in CC patients. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE CASTRO, GABRIELA S.; SIMOES, ESTEFANIA; LIMA, JOANNA D. C. C.; ORTIZ-SILVA, MILENE; FESTUCCIA, WILLIAM T.; TOKESHI, FLIVIO; ALCANTARA, PAULO S.; OTOCH, JOSE P.; COLETTI, DARIO; SEELAENDER, MARILIA. Human Cachexia Induces Changes in Mitochondria, Autophagy and Apoptosis in the Skeletal Muscle. CANCERS, v. 11, n. 9 SEP 2019. Web of Science Citations: 0.

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