Role of epigenetics in modulation of immune response at the junction of host-pathogen interaction and danger molecule signaling

Autor(es)

Morandini, Ana Carolina ; Santos, Carlos F. ; Yilmaz, Oezlem

• Tipo de documento: Artigo de Revisão
• Fonte: PATHOGENS AND DISEASE; v. 74, n. 7 OCT 2016.
• Citações Web of Science: 6

Resumo

Epigenetic mechanisms have rapidly and controversially emerged as silent modulators of host defenses that can lead to a more prominent immune response and shape the course of inflammation in the host. Thus, the epigenetics can both drive the production of specific inflammatory mediators and control the magnitude of the host response. The epigenetic actions that are predominantly shown to modulate the host defense against microbial pathogens are DNA methylation, histone modification and the activity of non-coding RNAs. There is also growing evidence that opportunistic chronic pathogens, such as Porphyromonas gingivalis, as a microbial host subversion strategy, can epigenetically interfere with the host DNA machinery for successful colonization. Similarly, the novel involvement of small molecule `danger signals', which are released by stressed or infected cells, at the center of host-pathogen interplay and epigenetics is developing. In this review, we systematically examine the latest knowledge within the field of epigenetics in the context of host-derived danger molecule and purinergic signaling, with a particular focus on host microbial defenses and infection-driven chronic inflammation.The authors systematically examine the latest advances in the field of epigenetics in the context of host-derived danger molecules and purinergic signaling, with a particular focus on host microbial defenses and infection-driven chronic inflammation.The authors systematically examine the latest advances in the field of epigenetics in the context of host-derived danger molecules and purinergic signaling, with a particular focus on host microbial defenses and infection-driven chronic inflammation. (AU)

• Processo FAPESP: 13/16113-9 - Papel da sinalização pelo receptor purinérgico P2X7 e das deacetilases de histona na resposta imune inata de fibroblastos humanos periodontais: Implicações na patogênese da periodontite
• Beneficiário: Ana Carolina Morandini Ramos
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 15/20954-4 - Papel da enzima nucleosídeo difosfato quinase de Porphyromonas gingivalis na modulação epigenética do receptor purinérgico P2X7
• Beneficiário: Ana Carolina Morandini Ramos
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Pós-Doutorado