Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Role of epigenetics in modulation of immune response at the junction of host-pathogen interaction and danger molecule signaling

Full text
Author(s):
Morandini, Ana Carolina ; Santos, Carlos F. ; Yilmaz, Oezlem
Total Authors: 3
Document type: Review article
Source: PATHOGENS AND DISEASE; v. 74, n. 7 OCT 2016.
Web of Science Citations: 6
Abstract

Epigenetic mechanisms have rapidly and controversially emerged as silent modulators of host defenses that can lead to a more prominent immune response and shape the course of inflammation in the host. Thus, the epigenetics can both drive the production of specific inflammatory mediators and control the magnitude of the host response. The epigenetic actions that are predominantly shown to modulate the host defense against microbial pathogens are DNA methylation, histone modification and the activity of non-coding RNAs. There is also growing evidence that opportunistic chronic pathogens, such as Porphyromonas gingivalis, as a microbial host subversion strategy, can epigenetically interfere with the host DNA machinery for successful colonization. Similarly, the novel involvement of small molecule `danger signals', which are released by stressed or infected cells, at the center of host-pathogen interplay and epigenetics is developing. In this review, we systematically examine the latest knowledge within the field of epigenetics in the context of host-derived danger molecule and purinergic signaling, with a particular focus on host microbial defenses and infection-driven chronic inflammation.The authors systematically examine the latest advances in the field of epigenetics in the context of host-derived danger molecules and purinergic signaling, with a particular focus on host microbial defenses and infection-driven chronic inflammation.The authors systematically examine the latest advances in the field of epigenetics in the context of host-derived danger molecules and purinergic signaling, with a particular focus on host microbial defenses and infection-driven chronic inflammation. (AU)

FAPESP's process: 13/16113-9 - Signaling by purinergic receptor P2X7 and histone deacetylases in the innate immune response of human periodontal fibroblasts: implications in the pathogenesis of periodontitis
Grantee:Ana Carolina Morandini Ramos
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 15/20954-4 - The role of Porphyromonas gingivalis-Nucleoside diphosphate kinase in epigenetic modulation of P2X7 receptor
Grantee:Ana Carolina Morandini Ramos
Support Opportunities: Scholarships abroad - Research Internship - Post-doctor