Effects of maternal protein restriction on the vascular pattern and protein expression in male Wistar rat epididymis at different stages of postnatal development

• Grant number: 15/18767-1
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: March 01, 2016
• End date: July 31, 2019
• Field of knowledge: Health Sciences - Medicine - Pathological Anatomy and Clinical Pathology
• Principal Investigator: Raquel Fantin Domeniconi
• Grantee: Marilia Martins Cavariani
• Host Institution: Instituto de Biociências (IBB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

Fetal programming is defined as a permanent change in the structure or function of the organism, due to alterations in development that occur in response to environmental stimuli. In this context, maternal nutrition has been shown to be important for the offspring health and studies provide evidence supporting the hypothesis that maternal nutritional status plays a crucial role in health and welfare of the fetus. Changes in maternal nutritional status may influence the mother's ability to provide to the fetus the nutrients needed for proper growth, impairing the physiological interactions between mother and conceptus. These interactions, may be mediated by hormonal signaling of LH, FSH, PRL, IGF-I , testosterone and aldosterone, which could cause epigenetic changes in regulatory genes of the target tissues. In adult animals, whose mothers experienced protein restriction, it has been observed a decrease in viability, motility and sperm concentration, as well as changes in the morphology of these gametes, parameters closely related to the epididymal function. However, there is no information in the literature to clarify how the protein restriction, at early stage of development, can affect function, development and vascular pattern of the epididymis, as well as the proteins levels associated with the maintenance of the specialized epididymal environment. Thus, the aim of this study is to investigate the pattern of histological, morphometric, immunohistochemical and molecular responses of the epididymis from Wistar rat offspring whose mothers were submitted to protein restriction during pregnancy and lactation period.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SANTOS, TALITA DE MELLO; CAVARIANI, MARILIA MARTINS; PEREIRA, DHRIELLY NATALIA; SCHIMMING, BRUNO CESAR; DE ALMEIDA CHUFFA, LUIZ GUSTAVO; DOMENICONI, RAQUEL FANTIN. Maternal Protein Restriction Modulates Angiogenesis and AQP9 Expression Leading to a Delay in Postnatal Epididymal Development in Rat. CELLS, v. 8, n. 9, SEP 2019. (16/04085-9, 17/23953-4, 15/18767-1)

CAVARIANI, MARILIA MARTINS; SANTOS, TALITA DE MELLO; PEREIRA, DHRIELLY NATALIA; DE ALMEIDA CHUFFA, LUIZ GUSTAVO; FELIPE PINHEIRO, PATRICIA FERNANDA; SCARANO, WELLERSON RODRIGO; DOMENICONI, RAQUEL FANTIN. Maternal Protein Restriction Differentially Alters the Expression of AQP1, AQP9 and VEGFr-2 in the Epididymis of Rat Offspring. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 20, n. 3, FEB 1 2019. (16/04085-9, 15/18767-1)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

CAVARIANI, Marilia Martins. Effects of maternal protein restriction on vascular pattern and on protein expression of the epididymis of male Wistar rats at different phases of postnatal development. 2019. Doctoral Thesis - Universidade Estadual Paulista (Unesp). Instituto de Biociências. Botucatu Botucatu.