Fatty acids as modulators of neutrophil recruitment, function and survival

Autor(es)

Rodrigues, Hosana G. ; Sato, Fabio Takeo ; Curi, Rui ; Vinolo, Marco A. R.

• Tipo de documento: Artigo Científico
• Fonte: European Journal of Pharmacology; v. 785, p. 50-58, AUG 15 2016.
• Citações Web of Science: 20

Resumo

Neutrophils are well-known to act in the destruction of invading microorganisms. They have also been implicated in the activation of other immune cells including B- and T-lymphocytes and in the resolution of inflammation and tissue regeneration. Neutrophils are produced in the bone marrow and released into the circulation from where they migrate to tissues to perform their effector functions. Neutrophils are in constant contact with fatty acids that can modulate their function, activation and fate (survival or cell death) through different mechanisms. In this review, the effects of fatty acids pertaining to five classes, namely, long-chain saturated fatty acids (LCSFAs), short-chain fatty acids (SCFAs), and omega-3 (n-3), omega-6 (n-6) and omega-9 (n-9) unsaturated fatty acids, on neutrophils and the relevance of these effects for disease development are discussed. (C) 2015 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 12/15774-9 - Aplicação de inibidores de histonas desacetilase no tratamento da obesidade e resistência à insulina associada
• Beneficiário: Fabio Takeo Sato
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 13/06810-4 - Mecanismos de ação dos ácidos graxos ômega-3 e ômega-6 no processo de reparo tecidual: enfoque neuro-imunológico
• Beneficiário: Hosana Gomes Rodrigues
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 12/10653-9 - Envolvimento dos ácidos graxos de cadeia curta e seu receptor (GPR43) na resposta imune a bactérias anaeróbias in vivo e in vitro
• Beneficiário: Marco Aurélio Ramirez Vinolo
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores