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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Type 2 Diabetes Remission After Roux-en-Y Gastric Bypass: Evidence for Increased Expression of Jejunal Genes Encoding Regenerating Pancreatic Islet-Derived Proteins as a Potential Mechanism

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Autor(es):
Sala, Priscila ; Torrinhas, Raquel Susana ; Fonseca, Danielle Cristina ; Heymsfield, Steven ; Giannella-Neto, Daniel ; Waitzberg, Dan Linetzky
Número total de Autores: 6
Tipo de documento: Artigo Científico
Fonte: OBESITY SURGERY; v. 27, n. 4, p. 1123-1127, APR 2017.
Citações Web of Science: 8
Resumo

Background Intestinal expression of regenerating pancreatic islet-derived protein-encoding genes (REG) would be enhanced after Roux-en-Y gastric bypass (RYGB) and would affect postoperative type 2 diabetes remission (T2Dr). Methods Intestinal biopsy samples were collected from 20 adult obese women with T2D before and 3 months after RYGB. Levels of REG expression and the gene encoding its putative receptor (EXTL3) were assessed by microarray and validated by quantitative RT-PCR. T2Dr was assessed according to ADA criteria 1 year after RYGB. Results After RYGB, only patients with T2Dr had significantly increased REG1 alpha and REG3 gamma expression in the jejunum, as validated by quantitative RT-PCR. Conclusions Our data provide support for the hypothesis that increased jejunal expression of REG genes after RYGB affects T2Dr, possibly by playing an endocrine function. (AU)

Processo FAPESP: 13/03246-0 - Estudo genômico, proteômico e metabolômico do tecido gastrointestinal de portadores de Diabetes melito tipo 2 após gastroplastia redutora a Y-Roux
Beneficiário:Priscila Sala Kobal
Linha de fomento: Bolsas no Brasil - Doutorado Direto
Processo FAPESP: 11/09612-3 - Alterações na expressão gênica do tecido gástrico e intestinal de portadores de Diabetes melito tipo 2 submetidos à gastroplastia redutora a Y-Roux
Beneficiário:Dan Linetzky Waitzberg
Linha de fomento: Auxílio à Pesquisa - Temático