Polymorphisms in SIGLEC1 contribute to susceptibility to pulmonary active tuberculosis possibly through the modulation of IL-1 beta

Autor(es)

de Lima, Dhemerson Souza ^[1] ; Nunes, Vinicius C. L. ^[1] ; Ogusku, Mauricio M. ^[2] ; Sadahiro, Aya ^[3] ; Pontillo, Alessandra ^[1] ; Alencar, Bruna de Cunha ^[4]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Ciencias Biomed, Dept Imunol, Lab Imunogenet, Sao Paulo, SP - Brazil

^[2] Inst Nacl de Pesquisas da Amazonia, Lab Micobacteriol, Manaus, AM - Brazil

^[3] Univ Fed Amazonas, Dept Parasitol, Lab Imunol Mol, Manaus, AM - Brazil

^[4] Univ Sao Paulo, Inst Ciencias Biomed, Dept Imunol, Lab Biol Celular Sistema Imune, Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: INFECTION GENETICS AND EVOLUTION; v. 55, p. 313-317, NOV 2017.
• Citações Web of Science: 2

Resumo

Siglec-1/CD169 is a sialoadhesin expressed by macrophages thought to function in cell-to-cell interactions. In the lung, the expression of Siglec-1 is specific for alveolar macrophages and single nucleotide polymorphisms (SNPs) in SIGLEC1 have been recently associated with asthma severity. Taking in account the role of alveolar macrophages in the control of M. tuberculosis and the poor literature about the contribution of SIGLEC1 genetics in M. tuberculosis susceptibility and development of pulmonary active TB, selected SNPs in SIGLEC1 were analysed in a case/control cohort from a TB endemic area of Brazil Amazon. Our findings evidenced for the first time the novel association between SIGLEC1 rs3859664 SNP and active pulmonary TB. Intriguingly, carriers of the polymorphism produced less IL-1 beta than non-carriers, suggesting the possible involvement of Siglec-1 signalling pathway with inflammasome complex. (AU)

• Processo FAPESP: 15/23395-6 - Imunogenetica do inflamassoma, estudo translacional "da clinica a bancada,da bancada a clinica":analise das variações nos genes do inflamassoma em doenças autoinflamatorias monogênicas e multifatoriais para diagnostico diferencial e aplicações terapêutica
• Beneficiário: Alessandra Pontillo
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 13/06142-1 - Perfil genômico da resposta imune ao HIV-1 e implicações para a vacina terapêutica com células dendríticas contra o HIV-1
• Beneficiário: Alessandra Pontillo
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 14/23225-0 - Papel das miosinas na trans-infecção do HIV-1 por células dendríticas e na replicação do HIV-1 em macrófagos
• Beneficiário: Bruna Cunha Gondim de Alencar
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores