Polymorphisms in SIGLEC1 contribute to susceptibility to pulmonary active tuberculosis possibly through the modulation of IL-1 beta

Author(s)

de Lima, Dhemerson Souza ^[1] ; Nunes, Vinicius C. L. ^[1] ; Ogusku, Mauricio M. ^[2] ; Sadahiro, Aya ^[3] ; Pontillo, Alessandra ^[1] ; Alencar, Bruna de Cunha ^[4]

Affiliation

^[1] Univ Sao Paulo, Inst Ciencias Biomed, Dept Imunol, Lab Imunogenet, Sao Paulo, SP - Brazil

^[2] Inst Nacl de Pesquisas da Amazonia, Lab Micobacteriol, Manaus, AM - Brazil

^[3] Univ Fed Amazonas, Dept Parasitol, Lab Imunol Mol, Manaus, AM - Brazil

^[4] Univ Sao Paulo, Inst Ciencias Biomed, Dept Imunol, Lab Biol Celular Sistema Imune, Sao Paulo, SP - Brazil

• Document type: Journal article
• Source: INFECTION GENETICS AND EVOLUTION; v. 55, p. 313-317, NOV 2017.
• Web of Science Citations: 2

Abstract

Siglec-1/CD169 is a sialoadhesin expressed by macrophages thought to function in cell-to-cell interactions. In the lung, the expression of Siglec-1 is specific for alveolar macrophages and single nucleotide polymorphisms (SNPs) in SIGLEC1 have been recently associated with asthma severity. Taking in account the role of alveolar macrophages in the control of M. tuberculosis and the poor literature about the contribution of SIGLEC1 genetics in M. tuberculosis susceptibility and development of pulmonary active TB, selected SNPs in SIGLEC1 were analysed in a case/control cohort from a TB endemic area of Brazil Amazon. Our findings evidenced for the first time the novel association between SIGLEC1 rs3859664 SNP and active pulmonary TB. Intriguingly, carriers of the polymorphism produced less IL-1 beta than non-carriers, suggesting the possible involvement of Siglec-1 signalling pathway with inflammasome complex. (AU)

• FAPESP's process: 15/23395-6 - Immunogenetics of the inflammasome and translational study "from bed to bench and back": analysis of variations in inflammasome genes in monogenic and multifactorial autoinflammatory diseases for differential diagnosis and therapeutic applications
• Grantee: Alessandra Pontillo
• Support Opportunities: Regular Research Grants
• FAPESP's process: 13/06142-1 - Genomic signature of immune response against HIV-1 and its implications for dendritic cell-based therapeutic vaccine against HIV-1
• Grantee: Alessandra Pontillo
• Support Opportunities: Regular Research Grants
• FAPESP's process: 14/23225-0 - Role of myosins in dendritic cell mediated trans-infection of HIV-1 and in HIV-1 replication in macrophages
• Grantee: Bruna Cunha Gondim de Alencar
• Support Opportunities: Research Grants - Young Investigators Grants