The Use of Jucara (Euterpe edulis Mart.) Supplementation for Suppression of NF-B Pathway in the Hypothalamus after High-Fat Diet in Wistar Rats

Autor(es)

Pisani, Luciana Pellegrini ^[7]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Dept Biociencias, BR-11015020 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Molecules; v. 23, n. 7 JUL 2018.
• Citações Web of Science: 4

Resumo

Obesity is associated with modern diets that are rich in saturated fatty acids. These dietary patterns are linked to low-grade proinflammatory mechanisms, such as the toll-like receptor 4/nuclear factor kappa-B (NF-B) pathway rapidly activated through high-fat diets. Jucara is a berry rich in anthocyanins and unsaturated fatty acids, which prevents obesity and associated comorbidities. We evaluated the effect of different doses of freeze-dried jucara pulp on NF-B pathway after the consumption of short-term high-fat diet. Male Wistar rats with ad libitum access to food and water were divided into four groups: Control diet (C), high-fat diet (HFC), high-fat diet with 0.25% jucara (HFJ 0.25%), and high-fat diet with 0.5% jucara (HFJ 0.5%). Energy intake and body weight gain were increased in HFC and HFJ 0.5% groups compared to C group. The hypothalamus weight reduced in the HFC group compared to C and HFJ 0.25% groups. Cytokines, MYD88, TRAF6, and pNF-Bp50 levels in the hypothalamus, serum triacylglycerol, LDL-cholesterol (LDL-C), and free fatty acid levels were improved in the HFJ 0.25% group. In summary, the HFJ 0.25% group had better protective effects than those in the HFJ 0.5%. Therefore, 0.25% jucara can be used to protect against central inflammation through the high-fat diet-induced NF-B pathway. (AU)

• Processo FAPESP: 16/14133-0 - Mecanismos intracelulares envolvidos com o processo inflamatório em indivíduos obesos antes e após a suplementação de polpa de juçara (Euterpe edulis Mart.)
• Beneficiário: Luciana Pellegrini Pisani
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 15/13875-0 - EFEITO DA SUPLEMENTAÇÃO DO FRUTO DA PALMEIRA JUÇARA (Euterpe edulis Mart.) NAS MODIFICAÇÕES EPIGENÉTICAS E ESTADO INFLAMATÓRIO EM MONÓCITOS DE ADULTOS OBESOS
• Beneficiário: Aline Boveto Santamarina
• Modalidade de apoio: Bolsas no Brasil - Doutorado