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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The Use of Jucara (Euterpe edulis Mart.) Supplementation for Suppression of NF-B Pathway in the Hypothalamus after High-Fat Diet in Wistar Rats

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Author(s):
Pisani, Luciana Pellegrini [7]
Total Authors: 1
Affiliation:
[1] Univ Fed Sao Paulo, Dept Biociencias, BR-11015020 Sao Paulo - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Molecules; v. 23, n. 7 JUL 2018.
Web of Science Citations: 4
Abstract

Obesity is associated with modern diets that are rich in saturated fatty acids. These dietary patterns are linked to low-grade proinflammatory mechanisms, such as the toll-like receptor 4/nuclear factor kappa-B (NF-B) pathway rapidly activated through high-fat diets. Jucara is a berry rich in anthocyanins and unsaturated fatty acids, which prevents obesity and associated comorbidities. We evaluated the effect of different doses of freeze-dried jucara pulp on NF-B pathway after the consumption of short-term high-fat diet. Male Wistar rats with ad libitum access to food and water were divided into four groups: Control diet (C), high-fat diet (HFC), high-fat diet with 0.25% jucara (HFJ 0.25%), and high-fat diet with 0.5% jucara (HFJ 0.5%). Energy intake and body weight gain were increased in HFC and HFJ 0.5% groups compared to C group. The hypothalamus weight reduced in the HFC group compared to C and HFJ 0.25% groups. Cytokines, MYD88, TRAF6, and pNF-Bp50 levels in the hypothalamus, serum triacylglycerol, LDL-cholesterol (LDL-C), and free fatty acid levels were improved in the HFJ 0.25% group. In summary, the HFJ 0.25% group had better protective effects than those in the HFJ 0.5%. Therefore, 0.25% jucara can be used to protect against central inflammation through the high-fat diet-induced NF-B pathway. (AU)

FAPESP's process: 16/14133-0 - Intracellular mechanisms implicated to inflammatory process in obese subjects before and after supplementation juçara pulp
Grantee:Luciana Pellegrini Pisani
Support Opportunities: Regular Research Grants
FAPESP's process: 15/13875-0 - EFFECT OF PALM JUÇARA FRUIT (Euterpe edulis Mart.) SUPPLEMENTATION ON EPIGENETIC MODIFICATIONS AND INFLAMMATORY STATUS IN MONOCYTES OF OBESE ADULTS.
Grantee:Aline Boveto Santamarina
Support Opportunities: Scholarships in Brazil - Doctorate