Regulation of autophagy as a therapy for immunosenescence-driven cancer and neurodegenerative diseases: The role of exercise

Autor(es)

Pereira Batatinha, Helena Angelica ^[1] ; Diniz, Tiego Aparecido ^[1] ; de Souza Teixeira, Alexandre Abilio ^[1] ; Krueger, Karsten ^[2] ; Rosa-Neto, Jose Cesar ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Cell & Dev Biol, 1524 Prof Lineu Prestes Av, BR-05508000 Sao Paulo, SP - Brazil

^[2] Leibniz Univ Hannover, Inst Sports Sci, Dept Exercise & Hlth, Hannover - Germany

• Tipo de documento: Artigo de Revisão
• Fonte: Journal of Cellular Physiology; v. 234, n. 9, p. 14883-14895, SEP 2019.
• Citações Web of Science: 3

Resumo

Aging is one of the risk factors for the development of low-grade inflammation morbidities, such as several types of cancer and neurodegenerative diseases, due to changes in the metabolism, hormonal secretion, and immunosenescence. The senescence of the immune system leads to improper control of infections and tissue damage increasing age-related diseases. One of the mechanisms that maintain cellular homeostasis is autophagy, a cell-survival mechanism, and it has been proposed as one of the most powerful antiaging therapies. Regular exercise can reestablish autophagy, probably through AMP-activated protein kinase activation, and help in reducing the age-related senescence diseases. Therefore, in this study, we discuss the effects of exercise training in immunosenescence and autophagy, preventing the two main age-related disease, cancer and neurodegeneration. (AU)

• Processo FAPESP: 16/10561-8 - Efeitos da suplementação de probióticos na modulação da microbiota oral e por consequência nas infecções do trato respiratório superior em corredores de longa distância.
• Beneficiário: Helena Angélica Pereira Batatinha
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 16/01409-8 - Caracterização do efeito antiinflamatório da suplementação com ácido palmitoleico na inflamação hepática; o papel dos ppars.
• Beneficiário: José Cesar Rosa Neto
• Modalidade de apoio: Auxílio à Pesquisa - Regular