de Lima, Diogenes S.
Cardozo, Lucas E.
Silveira, Eduardo L. V.
Amaral, Paulo P.
de Silva, Thushan I.
[4, 8, 9]
Nakaya, Helder I.
Número total de Autores: 11
Afiliação do(s) autor(es):
 Univ Sao Paulo, Sch Pharmaceut Sci, Dept Clin & Toxicol Anal, BR-05508000 Sao Paulo - Brazil
 Univ Chile, Fac Ciencias Quim & Farmaceut, Adv Ctr Chron Dis ACCDiS, Santiago 8380492 - Chile
 QIMR Berghofer Med Res Inst, Inflammat Biol Lab, Brisbane, Qld 4029 - Australia
 Gambia LSHTM, Vaccines & Immun Theme Med Res Council Unit, Banjul - Gambia
 Univ Cambridge, Gurdon Inst, Cambridge CB2 1QN - England
 GlaxoSmithKline, I-53100 Siena - Italy
 Imperial Coll London, Dept Infect Dis, London W12 ONN - England
 Imperial Coll London, Dept Med, Ctr Int Child Hlth, Paediat Sect, London W2 1PG - England
 Univ Sheffield, Dept Infect Immun & Cardiovasc Dis, Sheffield S10 2RX, S Yorkshire - England
 Univ Sao Paulo, Sci Platform Pasteur, BR-05508210 Sao Paulo - Brazil
Número total de Afiliações: 10
Tipo de documento:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA;
AUG 20 2019.
Citações Web of Science:
Understanding the mechanisms of vaccine-elicited protection contributes to the development of new vaccines. The emerging field of systems vaccinology provides detailed information on host responses to vaccination and has been successfully applied to study the molecular mechanisms of several vaccines. Long noncoding RNAs (lncRNAs) are crucially involved in multiple biological processes, but their role in vaccine-induced immunity has not been explored. We performed an analysis of over 2,000 blood transcriptome samples from 17 vaccine cohorts to identify lncRNAs potentially involved with antibody responses to influenza and yellow fever vaccines. We have created an online database where all results from this analysis can be accessed easily. We found that lncRNAs participate in distinct immunological pathways related to vaccine-elicited responses. Among them, we showed that the expression of lncRNA FAM30A was high in B cells and correlates with the expression of immunoglobulin genes located in its genomic vicinity. We also identified altered expression of these lncRNAs in RNA-sequencing (RNA-seq) data from a cohort of children following immunization with intranasal live attenuated influenza vaccine, suggesting a common role across several diverse vaccines. Taken together, these findings provide evidence that lncRNAs have a significant impact on immune responses induced by vaccination. (AU)