Exercise training attenuates insulin resistance and improves beta-cell function in patients with systemic autoimmune myopathies: a pilot study

Autor(es)

de Oliveira, Diego Sales ^[1] ; Pires Borges, Isabela Bruna ^[1] ; de Souza, Jean Marcos ^[1] ; Gualano, Bruno ^[1] ; Rodrigues Pereira, Rosa Maria ^[1] ; Shinjo, Samuel Katsuyuki ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Med, Hosp Clin HCFMUSP, Div Rheumatol, Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: CLINICAL RHEUMATOLOGY; v. 38, n. 12, p. 3435-3442, DEC 2019.
• Citações Web of Science: 0

Resumo

Introduction/objectives To assess the effects of exercise training on insulin resistance and beta-cell function in patients with systemic autoimmune myopathies (SAMs). Method This quasi-experimental, prospective study includes 9 patients with SAMs (six with dermatomyositis, two with antisynthetase syndrome, and one with polymyositis). Patients were submitted to a 12-week, twice a week, exercise training program comprising aerobic and resistance exercises. Baseline and after the intervention, we evaluated disease status, aerobic capacity, muscle strength, body composition, insulin resistance, and beta-cell function parameters. Results The patients have a mean age of 46.7 years and stable disease. No clinical or laboratory parameter impairment was observed after the intervention. Compared with baseline, aerobic capacity, muscle strength, and function increased after 12 weeks (P < 0.05), while no changes were observed for body composition. Data from the oral glucose tolerance test showed that exercise did not change glucose area under the curve (AUC), whereas insulin and C-peptide AUC decreased significantly (P < 0.05). Furthermore, Matsuda index and HOMA2 percentage (both surrogates of insulin resistance) also improved (P < 0.05). Conclusion Exercise training improved aerobic capacity, muscle strength, and muscle function in patients with SAMs. In addition, exercise training led to an attenuation of insulin resistance and improvements in beta-cell function parameters. These data indicate that exercise training can mitigate metabolic impairments, attenuating the cardiovascular risk in SAMs. (AU)

• Processo FAPESP: 16/19771-5 - Efeitos do treinamento físico no conteúdo lipídico e na resistência à ação da insulina do músculo esquelético de pacientes com miopatias inflamatórias idiopáticas: ensaio clínico controlado e randomizado
• Beneficiário: Diego Sales de Oliveira
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 16/20371-1 - Efeito do uso de hipolipemiantes na função endotelial e na rigidez vascular de pacientes com dermatomiosite e polimiosite: estudo prospectivo, duplo cego, randomizado e controlado
• Beneficiário: Isabela Bruna Pires Borges
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 17/13109-1 - Impacto do treinamento físico na resistência a ação da insulina, conteúdo lipídico, angiogênese e fibrogênese do músculo esquelético de pacientes com miopatias inflamatórias idiopáticas
• Beneficiário: Samuel Katsuyuki Shinjo
• Modalidade de apoio: Auxílio à Pesquisa - Regular