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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Caudate volume differences among treatment responders, non-responders and controls in children with obsessive-compulsive disorder

Texto completo
Autor(es):
Vattimo, Edoardo F. Q. [1] ; Barros, Vivian B. [2] ; Requena, Guaraci [3] ; Sato, Joao R. [4] ; Fatori, Daniel [1] ; Miguel, Euripedes C. [5] ; Shavitt, Roseli G. [1] ; Hoexter, Marcelo Q. [5] ; Batistuzzo, Marcelo C. [5]
Número total de Autores: 9
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Dept & Inst Psychiat, Hosp Clin HCFMUSP, Fac Med, R Dr Ovidio Pires de Campos 785, BR-01060970 Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Sch Publ Hlth, Sao Paulo, SP - Brazil
[3] Univ Sao Paulo, Dept Stat, Inst Math & Stat, Sao Paulo, SP - Brazil
[4] Univ Fed ABC, Ctr Math Comp & Cognit, Santo Andre, SP - Brazil
[5] Natl Inst Dev Psychiat Children & Adolescents INP, Sao Paulo, SP - Brazil
Número total de Afiliações: 5
Tipo de documento: Artigo Científico
Fonte: EUROPEAN CHILD & ADOLESCENT PSYCHIATRY; v. 28, n. 12, p. 1607-1617, DEC 2019.
Citações Web of Science: 1
Resumo

Treatment response in obsessive-compulsive disorder (OCD) is heterogeneous and the neurobiological underpinnings of such variability are unknown. To investigate this issue, we looked for differences in brain structures possibly associated with treatment response in children with OCD. 29 children with OCD (7-17 years) and 28 age-matched controls underwent structural magnetic resonance imaging. Patients then received treatment with fluoxetine or group cognitive-behavioral therapy during 14 weeks, and were classified as treatment responders or non-responders. The caudate nucleus, thalamus and orbitofrontal cortex were selected a priori, according to previous evidence of their association with OCD and its treatment. Gray matter (GM) volume comparisons between responders, non-responders and controls were performed, controlling for total GM volume. 17 patients were classified as responders. Differences among responders, non-responders and controls were found in both caudate nuclei (both p-values=0.041), but after Bonferroni correction for multiple comparisons, these findings were non-significant. However, after excluding the effect of an outlier, findings were significant for the right caudate (p=0.004). Pairwise comparisons showed larger caudate GM volume in responders versus non-responders and controls, bilaterally. The right caudate accounted for 20.2% of the variance in Y-BOCS changes after treatment in a linear regression model, with a positive correlation (p=0.016). We present a possible neural substrate for treatment response in pediatric OCD, which is in line with previous evidence regarding the caudate nucleus. Considering the limitations, further research is needed to replicate this finding and elucidate the heterogeneity of treatment response in children with OCD. (AU)

Processo FAPESP: 18/21934-5 - Estatística de redes: teoria, métodos e aplicações
Beneficiário:André Fujita
Linha de fomento: Auxílio à Pesquisa - Temático
Processo FAPESP: 14/50917-0 - INCT 2014: psiquiatria do desenvolvimento para crianças e adolescentes
Beneficiário:Eurípedes Constantino Miguel Filho
Linha de fomento: Auxílio à Pesquisa - Temático
Processo FAPESP: 13/08531-5 - Coorte de alto risco para transtornos psiquiátricos na infância: seguimento de neuroimagem após 3 anos
Beneficiário:Andrea Parolin Jackowski
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 18/04654-9 - Séries temporais, ondaletas e dados de alta dimensão
Beneficiário:Pedro Alberto Morettin
Linha de fomento: Auxílio à Pesquisa - Temático
Processo FAPESP: 09/09949-8 - Ativação cerebral associada à memória episódica verbal no Transtorno Obsessivo-Compulsivo (TOC): análise por ressonância magnética funcional
Beneficiário:Marcelo Camargo Batistuzzo
Linha de fomento: Bolsas no Brasil - Doutorado Direto